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Determination of human chorionic gonadotropin

Best Practice & Research Clinical Endocrinology & Metabolism, 2013
Determination of human chorionic gonadotropin (hCG) is used for diagnosis and monitoring of pregnancy, pregnancy related disorders, for trophoblastic and some nontrophoblastic tumors. In addition, hCG is determined for doping control in males. Assay of hCG is complicated by the occurrence of different molecular forms, which are detected to various ...
Alfthan Henrik   +3 more
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Radioimmunoassay for human chorionic gonadotropin

American Journal of Obstetrics and Gynecology, 1968
Abstract A radioimmunoassay method for HCG utilizing I 125 for iodination and a chemical procedure for separation of free and bound HCG 125 are described. This method is more sensitive and more accurate than the hemagglutination inhibition technique.
Y, Tomoda, M M, Hreshchyshyn
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Human chorionic gonadotropin in cancer

Clinical Biochemistry, 2004
Human chorionic gonadotropin (hCG) is mainly used for detection and monitoring of pregnancy and pregnancy-related disorders but it is also an extremely sensitive and specific marker for trophoblastic tumors of placental and germ cell origin. Thus treatment of relapsing choriocarcinomas and testicular germ cell tumors is often initiated on the basis of ...
Ulf-Håkan, Stenman   +2 more
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Immunocytochemistry of human chorionic gonadotropin in human chorionic villi

American Journal of Obstetrics and Gynecology, 1987
The immunocytochemical localization of human chorionic gonadotropin was investigated in chorionic villi from the seventh to twelfth week of gestation. By the light microscopic peroxidase-antiperoxidase technique, positive reactions of human chorionic gonadotropin were found exclusively in the syncytiotrophoblast.
K, Hamasaki   +4 more
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Studies of Human Chorionic Gonadotropin

1971
Publisher Summary This chapter focuses on human chorionic gonadotropin (HCG), a glycoprotein hormone produced by the placenta that appears in significant quantities in the urine during the first trimester of pregnancy. The mean level of urinary HCG produced during the first trimester is 30,000–50,000 IU in 24 hours, equivalent to a maximum of ...
R E, Canfield   +4 more
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Antibodies to human chorionic gonadotropin in humans

Clinica Chimica Acta, 1981
Very few observations have been published about the development of antibodies against gonadotropins in the human. Human FSHand hCG-antibodies have been detected in a patient with isolated FSH-deficiency after human menopausal gonadotropin administration [l], or after human menopausal (hMG) and chorionic gonadotropin (hCG) administration in women with ...
K, Musch, A S, Wolf, C, Lauritzen
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Human Chorionic Gonadotropin

2021
HCG is a hormone unique to gestation, however, it may be raised in other pathological conditions as well. Human chorionic gonadotropin (hCG) is a placental hormone secreted after implantation and is commonly detected by urine gravindex test. It interacts with the LHCG receptor of the ovary and maintains the corpus luteum during initial weeks of ...
Ashok Kumar Padhy   +2 more
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Biosynthesis of Human Chorionic Gonadotropin*

Endocrine Reviews, 1980
HUMAN chorionic gonadotropin (hCG) is a glycoprotein hormone normally secreted by trophoblastic cells of the placenta during pregnancy. Trophoblastic tumors and some nontrophoblastic tumors also secrete hCG and/or its α- or β-subunit. This review emphasizes a number of aspects, some controversial, of hCG biosynthesis and secretion that have received ...
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Immunochemistry of Human Chorionic Gonadotropin

1984
In states of gestational trophoblastic disease, knowledge of the immunochemistry of human chorionic gonadotropin (hCG) is principally of value in relation to its use as a diagnostic tool and as a marker for the persistence of disease activity during chemotherapy (1, 2).
R E, Canfield   +3 more
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Human chorionic gonadotropin tests

Expert Review of Molecular Diagnostics, 2009
Human chorionic gonadotropin (hCG) is not a single biological molecule. There is the regular form of hCG produced by differentiated syncytotrophoblast cells (regular hCG). This hormone primarily functions to maintain the myometrial and decidual spiral arteries, or the vascular supply of the placenta during the full course of pregnancy ...
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