Results 141 to 150 of about 134,051 (264)

A descriptive case series of hepatotoxicity associated with CFTR modulators and possible relevance of pharmacogenetic polymorphisms in cystic fibrosis patients

British Journal of Clinical Pharmacology, EarlyView.
Cystic fibrosis transmembrane conductance regulator (CFTR) modulators are widely used in patients with cystic fibrosis and significantly improve respiratory function and quality of life. However, their effectiveness may be limited by liver damage, which sometimes leads to treatment discontinuation, and the mechanisms underlying this remain poorly ...
Clara Laffitte Redondo, Venceslas Bourdin, Abd El Kader Ait Tayeb, Sihem Benaboud, Inès Martins, Caroline Joyau, Myriam Benhamida, Isabelle Sermet‐Gaudelus, Clémence Martin, Pierre Régis Burgel, Céline Verstuyft, Laurent Chouchana, Estelle Ayme‐Dietrich   +12 more
wiley   +1 more source

Valganciclovir Therapy Prevents Human Cytomegalovirus Reactivation in Glioblastoma Patients Undergoing Radiochemotherapy and Extends Time to Tumor Progression. [PDF]

Cancers (Basel)
Pantalone MR, Stragliotto G, Martin-Almazan N, Peredo-Harvey I, Jimenez-Macias JL, Rahbar A, Lawler S, Bartek J, Söderberg-Naucler C.   +8 more
europepmc   +1 more source

Fouling‐Free Inertial Microfluidic Cell Clarification for Lentivirus Manufacturing

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Lentiviral vectors (LVVs) are widely used as gene‐delivery vehicles in cell and gene therapy, enabling stable integration of transgenes into target cells. However, efficient clarification of LVV harvest remains a major bottleneck in large‐scale manufacturing, as conventional depth filtration often results in significant product loss.
Dohyun Park, Alexander Bevacqua, Mingyang Cui, Marina Nichols, Jianzhu Chen, Jongyoon Han   +5 more
wiley   +1 more source

Human cytomegalovirus reactivation in decompensated cirrhosis: marker of immunosuppression or contributor to severity?: Editorial on "Human cytomegalovirus reactivation in cirrhosis patients with acute decompensation". [PDF]

Clin Mol Hepatol
Cao Z, Moreau R.
europepmc   +1 more source

Engineering Stable Lentiviral Vector Producer Cells Improves LVV Production

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Stable lentiviral vector producer cell lines represent a promising platform for scalable and cost‐efficient vector manufacturing, yet their productivity is often limited by intrinsic host‐cell constraints. In this study, we aimed to identify cellular factors restricting LVV production in stable doxycycline‐inducible GPRTG producer cell lines ...
Jona Röscheise, Lena‐Marie Eberle, Holger Laux, Kerstin Otte   +3 more
wiley   +1 more source

Coding-complete genome of human cytomegalovirus extracted from a nasopharyngeal swab in Brazil. [PDF]

Microbiol Resour Announc
Cruz AMS, Sousa EC, Barbagelata LS, das Chagas WD, Nunes AMS, Livorati MTFP, de Almeida WAF, da Trindade JF, Costa AS, Tavares FN, de Sousa MS, Dos Santos MC.   +11 more
europepmc   +1 more source

Organising for Circularity: An Empirical Analysis of Project Organising and the Development of Circular Economy Firm Capabilities

Business Strategy and the Environment, EarlyView.
ABSTRACT Firms pursue the circular economy (CE) by using projects as organisational forms. However, the transformative role of project organising (PO) in developing circular firm capabilities (FC) remains underexplored. In this study, we examine the effects of PO on the development of critical circular FC in CE‐based firms. We draw on primary data from
Ambisisi Ambituuni, Hakeem Sunmola, Emmanouil Tyllianakis, Oluwaseun Kolade, Soroush Abolfathi, Muyiwa Oyinlola   +5 more
wiley   +1 more source

Shining a light on viral detection: a comparative study of electrochemical and electrochemiluminescence techniques for human cytomegalovirus. [PDF]

Anal Bioanal Chem
Fried A, Itterheimova K, Moranova L, Bartosik M.   +3 more
europepmc   +1 more source

Human Cytomegalovirus

Transfusion Medicine and Hemotherapy, 2005
openaire   +1 more source

Sustainability Orientation and Entrepreneurial Performance in Resource‐Constrained Contexts

Business Strategy and the Environment, EarlyView.
ABSTRACT This study examines how sustainability orientation shapes entrepreneurial performance in bottom‐of‐the‐pyramid (BoP) markets by theorizing responsible entrepreneurship as a central mechanism and BoP orientation as a contextual contingency. Using survey data from 283 small‐ and medium‐sized enterprises (SMEs) in Ghana, we integrate perspectives
George Obeng Dankwah, Hayford Amegbe, Dafleen Addrah, Oghogho Destina Ovuakporie, Lydia Nyankom Takyi, Samuel Adomako   +5 more
wiley   +1 more source