Results 161 to 170 of about 9,097,628 (294)

DTX3 Suppresses the NPM3–RUVBL1 Axis to Inhibit Homologous Recombination Repair and Abrogate Tumor Radioresistance

Advanced Science, EarlyView.
Deltex 3 (DTX3) catalyzes K27‐linked ubiquitination of nucleophosmin 3 to disrupt homologous recombination repair and reverse tumor radioresistance. Low DTX3 predicts poor survival and radiotherapy recurrence, serving as a radiosensitizing therapeutic target.
Jia‐Hao Xiao, Chang‐Jun Xie, Yan‐Hua Chen, Hao Cheng, Shuang‐Hui Li, Wei Li, Ya‐Wen Bin, Rui‐Min He, Ying‐Qing Li, Ping Feng   +9 more
wiley   +1 more source

The C-Type Lectin Mincle Serves as a Pattern Recognition Receptor for the Lipid Envelope of Human Cytomegalovirus. [PDF]

Eur J Immunol
Bokun V, Chai W, Buchanan R, Murphy E, Liu Y, Holder B, Decout A.   +6 more
europepmc   +1 more source

PHGDH‐Mediated Serine Metabolism in Nucleus Pulposus Cells Is a Potential Therapeutic Target for Intervertebral Disc Degeneration

Advanced Science, EarlyView.
When nucleus pulposus cells senesce, PHGDH decreases, reducing serine synthesis and glutathione, impairing antioxidant capacity. The intermediate α‐KG also drops, lowering JMJD3 demethylase activity, increasing H3K27me3 at the Rap1b promoter, and reducing Rap1b expression, whose down‐regulation in turn activates mTORC1 and suppresses autophagy ...
Hao‐Wei Xu, Sheng‐Jie Chang, Xiao‐Wei Liu, Shu‐Bao Zhang, Ying‐Jie Wang, Shan‐Jin Wang   +5 more
wiley   +1 more source

UL45 of Human Cytomegalovirus Promotes Macrophage Survival and Modulates RIPK3-Associated Cell Death. [PDF]

Viruses
Yu CS, Beeton K, Daley-Bauer LP, Stray SJ.   +3 more
europepmc   +1 more source

ADISSP Drives Metabolic Reprogramming and Immune Suppression to Regulate Hepatocellular Carcinoma Progression and Immunotherapy Sensitivity

Advanced Science, EarlyView.
In HCC, ADISSP sustains IKKβ/NF‐κB signaling by inhibiting PPP1CA‐mediated IKKβ dephosphorylation, thereby inducing the expressions of SLC16A3 and CCL20. SLC16A3‐driven lactate remodeling promotes glycolysis, ferroptosis resistance, and M2 macrophage polarization, whereas CCL20 facilitates macrophage recruitment.
Tuan‐Song Zhang, Chen Xiong, Chen Yang, Yu‐Chuan Yan, Jie Li, Rui‐Zhe Li, Guo‐Qiang Pan, Jie Zou, Xiao‐Lu Zhang, Tao Li, Zhao‐Ru Dong   +10 more
wiley   +1 more source

[Corrigendum] Human cytomegalovirus RL13 protein interacts with host NUDT14 protein affecting viral DNA replication. [PDF]

Mol Med Rep
Wang G, Ren G, Cui X, Lu Z, Ma Y, Qi Y, Huang Y, Liu Z, Sun Z, Ruan Q.   +9 more
europepmc   +1 more source

Single‐Cell Map of Early Lung Adenocarcinoma Uncovers Invasion‐Associated Tertiary Lymphoid Structures

Advanced Science, EarlyView.
Early thoracic lesions are already heavily infiltrated by immune cells, yet these infiltrates largely consist of bystander T lymphocytes within an immunosuppressive microenvironment. Pathological invasion is strikingly associated with the neogenesis of T/B cell‐rich TLSs that predominantly remain immature.
Pengfei Ma, Chunming He, Mei‐Chun Cai, Jie Wu, Haijiao Lu, Shichao Zhou, Zhenfeng Zhang, Qing Zhang, Yunqing Chen, Jingyu Zang, Kaiyan Ye, Yu Shu, Chee Wai Chua, Hui Li, Yun Fan, Jing Wang, Zhuang Yu, Xinying Xue, Xiaojing Zhao, Guanglei Zhuang, Yujie Fu   +20 more
wiley   +1 more source

The human cytomegalovirus vGPCR UL33 is essential for efficient lytic replication in epithelial cells. [PDF]

J Virol
Freeman MR, Dooley AL, Groves IJ, Wright J, Beucler MJ, Baruah V, Qi X, Sanders W, Moorman NJ, O'Connor CM, Miller WE.   +10 more
europepmc   +1 more source

High Diagnosis Rate for Nonimmune Hydrops Fetalis With Prenatal Clinical Genome: Expanded Results From the Hydrops‐Yielding Diagnostic Results of Prenatal Sequencing (HYDROPS) Study

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Nonimmune hydrops fetalis (NIHF) is characterized by abnormal fluid accumulation in ≥ 2 fetal compartments and may be genetic. The incremental diagnostic yield of prenatal exome sequencing (ES) for NIHF following a negative standard workup was previously explored on 22 cases.
Stephanie M. Rice, Mona M. Makhamreh, Sascha Wodoslawsky, Mariella Toro, Elizabeth Critchlow, Brandy Firman, Ruby Liu, Babi Ramesh Nallamilli, Madhuri Hegde, Seth I. Berger, Huda B. Al‐Kouatly   +10 more
wiley   +1 more source

Glutamine supports human cytomegalovirus induced lipidome remodeling through reductive carboxylation. [PDF]

PLoS Pathog
Mokry RL, de Lacy CB, Purdy JG.
europepmc   +1 more source