Results 201 to 210 of about 8,732,052 (351)

Polydatin alleviates mitochondrial damage and apoptosis of lung epithelial cells by inhibiting toll‐like receptor 4‐dependent macrophage activation in asthma

Animal Models and Experimental Medicine, EarlyView.
The alleviation of asthma by polydatin is dependent on the blockage of the toll‐like receptor 4 (TLR4)/P2X7R synergy in macrophages. The blockage of the TLR4/P2X7R synergy results in decreased release and secretion of interleukin‐1β (IL‐1β) and IL‐18. In epithelial cells, low IL‐1β and IL‐18 levels inhibit mitochondrial damage and apoptosis.
Guangxing Li, Ruobai Liu, Chang Xu, Jianing Yang, Yilan Song, Li Li, Jingzhi Jiang, Liangchang Li, Chongyang Wang, Guanghai Yan   +9 more
wiley   +1 more source

Palmitoylation of the human cytomegalovirus tegument protein pp28 facilitates virus release. [PDF]

PLoS Pathog
Lee JB, Koo N, Park JM, Seo JY.
europepmc   +1 more source

Transcriptome-wide characterization of human cytomegalovirus in natural infection and experimental latency

Proceedings of the National Academy of Sciences of the United States of America, 2017
Shu-Xia Cheng, K. Caviness, J. Buehler, M. Smithey, J. Nikolich-Žugich, Felicia D. Goodrum   +5 more
semanticscholar   +1 more source

Generating golden Syrian hamsters with conditional alleles via zygote microinjection of CRISPR/Cas9

Animal Models and Experimental Medicine, EarlyView.
We established the first conditional knockout (cKO) model in the golden Syrian hamster by CRISPR/Cas9‐mediated genome editing. Cas9 protein, two sgRNAs, and a donor plasmid carrying loxP‐flanked exon 2 of the ApoF gene were microinjected into one‐cell embryos. The floxed allele was efficiently generated (up to 27%) and transmitted through the germline.
Wei Chen, Xu Zhang, Rui Fan, Xia Li, Feifei Guan, Gefan Wan, Weining Kong, Xiaolong Qi, Shuo Pan, Sijing Shi, Yuanlong Su, Shan Gao, Wei Huang, Xunde Xian, Jiangning Liu, Yuhui Wang, Yuanwu Ma   +16 more
wiley   +1 more source

Characterization of innate lymphoid cells in infants with human cytomegalovirus infection. [PDF]

BMC Pediatr
Li L, Yang Q, Liu X, Li S, Zhao S, Ye Z, Yi S, Li Y, Peng H, Wu S, Hao F, Deng Y, Deng Y.   +12 more
europepmc   +1 more source

Human cytomegalovirus reprogrammes haematopoietic progenitor cells into immunosuppressive monocytes to achieve latency

Nature Microbiology, 2018
Dihan Zhu, Chaoyun Pan, Jingxue Sheng, Hongwei Liang, Zhen Bian, Yuan Liu, P. Trang, Jianguo Wu, Fenyong Liu, Chen-Yu Zhang, Ke Zen   +10 more
semanticscholar   +1 more source

Characterization of inflammatory pseudotumors in a large animal model of liver cancer

Animal Models and Experimental Medicine, EarlyView.
CT images in arterial and portal venous phases of liver lesions in Oncopig. Abstract Background The development of relevant and robust large animal models of hepatocellular carcinoma is needed to test new therapeutic strategies for this disease. Transgenic approaches hold promise in addressing this complex problem. One such model, the Oncopig, has been
Erik N. K. Cressman, Samantha Hicks, Natalie W. Fowlkes, Danielle L. Stolley, Maria Sophia Stenkamp   +4 more
wiley   +1 more source

Does human cytomegalovirus provide a novel therapeutic target for patients with glioblastoma? [PDF]

Philos Trans R Soc Lond B Biol Sci
Söderberg-Naucler C, Pantalone MR, Stragliotto G, Bartek J.   +3 more
europepmc   +1 more source

Venous thromboembolism related to cytomegalovirus infection: A case report and literature review [PDF]

, 2017
Farrell, John J, Jacob, Kavitha S, Kelkar, Amar H, Yousif, Eman B   +3 more
core   +2 more sources

The complexity of dementia development and its comorbidities: The collaborative cross‐mouse population for multivarious tasks approach

Animal Models and Experimental Medicine, EarlyView.
The increasing prevalence of dementia and related neurodegenerative diseases—including Alzheimer's disease, Parkinson's disease, multiple sclerosis, and amyotrophic lateral sclerosis—poses a growing public health challenge. These conditions have traditionally been studied as isolated central nervous system disorders, but emerging evidence points to ...
Osayd Zohud, Iqbal M. Lone, Kareem Midlej, Fuad A. Iraqi   +3 more
wiley   +1 more source