Results 91 to 100 of about 34,966,316 (347)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
The Subnational Human Development Database
Scientific Data, 2019 In this paper we describe the Subnational Human Development Database. This database contains for the period 1990–2017 for 1625 regions within 161 countries the national and subnational values of the Subnational Human Development Index (SHDI), for the ...
J. Smits, I. Permanyer
semanticscholar +1 more source
International Migration and Human Development [PDF]
This paper reviews the relationship between international migration and human development. First, it reviews what we know about the factors that drive migration from developing to developed countries.
Dean Yang
core +3 more sources
FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Robust human development rankings [PDF]
The United Nations' Human Development Index (HDI) takes several dimensions ---income, school enrolment and literacy rate, longevity--- and combines them into a single figure that measures the degree of development of a given country.
Erwin Oghe +2 more
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Construction vs. Development: Polarizing Models of Human Gestation [PDF]
, 2014 This essay argues that the polarization of our public debate over embryo-destructive research may be due, to a large extent, not to different valuations of individual human life but to different conceptions of the process of gestation, with one group ...
Stith, Richard
core +3 more sources
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Circular Migration and Human Development [PDF]
This paper explores the human development implications of circular migration — both where it occurs naturally and where governments work to create it.
Kathleen Newland
core +3 more sources
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Human Development and Shelter: A Human Rights Perspective [PDF]
human development, poverty ...
Clarence J. Dias and Scott Leckie
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