Results 141 to 150 of about 34,966,316 (347)
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Inquiry: The Journal of Health Care Organization, Provision, and FinancingCompassionate, respectful, and caring (CRC) programs have been introduced in Ethiopian health facilities in the last 5 years to transform health care quality and provide patient-centered, compassionate, and respectful care. Therefore, this study aimed to
Kemal Jemal BSc, MSc +8 more
doaj +1 more source
Law, economic growth and human development [PDF]
This paper cuts adrift the mainstream approach to the legal-origins debate on the law-growth nexus by integrating both overall economic and human components in our understanding of how regulation quality and the rule of law lie at the heart of economic ...
Simplice A., Asongu
core +1 more source
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
The Political Economy of Human Development [PDF]
What are the causes and consequences of human development? In the twenty years since the publication of the first Human Development Report (HDR), political scientists have invested a great deal of time and effort into answering this question.
Leonard Wantchekon, Robin Harding
core
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
The Role of Social Support in Mediating Stress and Depression
Online Journal of Health & Allied Sciences, 2017 As important as it is to fully comprehend the relationship between stress and depression among university students, it is also vital to ascertain the role of perceived social support as an essential psychosocial factor for effectively delimiting the ...
Prashanth Talwar +5 more
doaj
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Planetary boundaries: Guiding human development on a changing planet
Science, 2015 Will Steffen +17 more
semanticscholar +1 more source
MEASURING HUMAN WELLBEING AND ADVANCING SUSTAINABLE DEVELOPMENT: HOW CREDIBLE ARE THE UNDP'S HUMAN DEVELOPMENT REPORTS? [PDF]
The broad objectives of the Human Development Report (HDR) and the estimates of human wellbeing are to identify policies that reduce poverty, economic and gender inequalities inequalities and increase human wellbeing. Since inception in 1990, the HDR and
Chieko Tokuyama, J. Ram Pillarisetti
core