Results 191 to 200 of about 4,226,351 (268)

Trends in net survival from cervical cancer in a Brazilian state with medium Human Development Index. [PDF]

Sci Rep
da Silva BEB, Di Carlo V, Minicozzi P, Ssenyonga N, Khan Baloch F, Matz M, Coleman MP, Allemani C, Lima CA.   +8 more
europepmc   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Ecological condition of mountain lakes in the conterminous United States and vulnerability to human development. [PDF]

Ecol Indic
Handler AM, Weber M, Dumelle M, Jansen LS, Carleton JN, Schaeffer BA, Paulsen SG, Barnum T, Rea AW, Neale A, Compton JE.   +10 more
europepmc   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

MYCN in human development and diseases. [PDF]

Front Oncol
Nishio Y, Kato K, Oishi H, Takahashi Y, Saitoh S.   +4 more
europepmc   +1 more source

PARP inhibitors induce a senescence phenotype in non‐small cell lung carcinoma cell lines

FEBS Open Bio, EarlyView.
Talazoparib is the most potent inducer of senescence among different PARP1 inhibitors in human NSCLC cells. In the absence of PARP, no senescence phenotype was observed, demonstrating that PARP1 is necessary for the induction of senescence by this inhibitor.
Camille Huart, Manon Van den Abbeel, Christoph Schifflers, Karim Bouhjar, Andrea Scarmelotto, Alexis Khelfi, Anne‐Catherine Wera, Carine Michiels   +7 more
wiley   +1 more source

Stem cell-based models of early human development.

Development
Liu L, Wu J.
europepmc   +1 more source

Trends and patterns of global health risk factors (2015-2019): a composite index approach across 100 countries stratified by human development index groups. [PDF]

J Health Popul Nutr
Junaid KP, Kiran T, Gupta M, Kishore K, Siwatch S.   +4 more
europepmc   +1 more source

Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains

FEBS Open Bio, EarlyView.
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth, Moritz Koch, Le‐Han Rössner, Johanna Eichhorn, Denys Pogoryelov, Matthias P. Mayer, Jude M. Przyborski   +6 more
wiley   +1 more source

Toward a Unified Model of Advanced Meditation, Human Development, Meditation Maps, and Transtradition Metaphors: Facing Impermanence, Suffering, and Death. [PDF]

Mindfulness (N Y)
Sparby T, Sacchet MD.
europepmc   +1 more source