Results 201 to 210 of about 4,384,767 (266)

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Bridging divides or deepening gaps? ICT, quality of life, and the challenge of inclusive development at the intersection of healthcare and human development in South Asia. [PDF]

BMC Public Health
Akbar M, Tang W, Hussain A, Poulova P.
europepmc   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

MYCN in human development and diseases. [PDF]

Front Oncol
Nishio Y, Kato K, Oishi H, Takahashi Y, Saitoh S.   +4 more
europepmc   +1 more source

Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma

Molecular Oncology, EarlyView.
Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara, Kosuke Murakami, Shiro Takamatsu, Akiko Kanto, Seiichi Mori, Tomoyuki Otani, Kazuko Sakai, Yasushi Kotani, Kazuto Nishio, Kaoru Abiko, Noriomi Matsumura   +10 more
wiley   +1 more source

Effects of human development, primary care coverage and the COVID-19 pandemic on the fertility rate among adolescents in Brazil in the period 2012-2021. [PDF]

PLoS One
Domingues RMSM, Herzog RSA, Dias MAB, Francisco RPV, Rodrigues AS.   +4 more
europepmc   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Trends in net survival from cervical cancer in a Brazilian state with medium Human Development Index. [PDF]

Sci Rep
da Silva BEB, Di Carlo V, Minicozzi P, Ssenyonga N, Khan Baloch F, Matz M, Coleman MP, Allemani C, Lima CA.   +8 more
europepmc   +1 more source

Does the trade of medical products contribute to promoting human development?-An empirical analysis based on data from China and RCEP countries. [PDF]

Front Public Health
Wu L, Liu W, Zhou J, Zhou D, Xiao H.
europepmc   +1 more source

Ecological condition of mountain lakes in the conterminous United States and vulnerability to human development. [PDF]

Ecol Indic
Handler AM, Weber M, Dumelle M, Jansen LS, Carleton JN, Schaeffer BA, Paulsen SG, Barnum T, Rea AW, Neale A, Compton JE.   +10 more
europepmc   +1 more source