Results 111 to 120 of about 597,824 (308)
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
The Universal Alliance of All Peoples : Romantic Socialists, the Human Family, and the Defense of Empire during the July Monarchy, 1830-1848 [PDF]
, 2011 This article documents the procolonial rhetoric among romantic socialists in France during the July Monarchy (1830-48), demonstrating its pervasiveness.
Andrews, Naomi J.
core +1 more source
Human Development Report 2000: Human Rights and Human Development [PDF]
, 2000 The Human Development Report 2000 looks at human rights as an intrinsic part of development—and at development as a means to realizing human rights. It shows how human rights bring principles of accountability and social justice to the process of human development.
openaire
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source
A Blend of Absurdism and Humanism: Defending Kurt Vonnegut’s Place in the Secondary Setting [PDF]
, 2018 This essay argues that Kurt Vonnegut blends a unique humanist stance into his absurdist plots and characters, ultimately urging readers to confront the absurd with a kindness and human decency his protagonists often find rare.
Johnson, Krisandra R
core +1 more source
FEBS Letters, EarlyView.Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas +3 more
wiley +1 more source
The Letter of the Law: The Scope of the International Legal Obligation to Prosecute Human Rights Crimes [PDF]
, 1996 While international criminal conventions are limited in their application, there is growing recognition of a duty for states to do something to give meaning to human ...
Scharf, Michael
core +1 more source
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
Jiaoshi jiaoyu xuebaoKant's fundamental understanding of education plays a basic role and provides significant inspiration for the development of educational disciplines.
YANG Mei, ZHANG Wei
doaj +1 more source