Results 101 to 110 of about 597,824 (308)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
The Modern Idea of Progress by Jean A. Condorcet [PDF]
Studia Warmińskie, 2017 The 18th century is the opening to cognitive progress (epistemology) which becomes the core of historical progress. They were defined more precisely by Robert Turgot (1727-1781).
Podgórski Ryszard
doaj
Governance, Decentralisation, and Poverty: The Case of Pakistan [PDF]
Human development and human rights share a common vision and purpose: to secure the freedom, well being and dignity of humanity. Human development is as essential for human rights as the latter is for the former.
Sehar Rizvi, Zafar H. Ismail
core
Bettering Humanity through Biology [PDF]
, 2018 Biology is arguably referred to as the “science of the XXIth century”. This prestigious title intrinsically contains a huge responsibility. For many centuries, Biology has contributed directly or indirectly to bettering humankind, although its obvious ...
Mota, Manuel
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FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
THE THEORY OF CIVILIZATIONS THROUGH THE LENS OF CONTEMPORARY HUMANITIES
Antropologìčnì Vimìri Fìlosofsʹkih Doslìdžen', 2016 Purpose. This paper invites reflections on the further development of civilizational theory through the lens of contemporary humanities. It argues that philosophy is one of the key dimensions of the integral theory of civilizations.
T. V. Danylova
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From Völkerpsychologie to Cultural Anthropology: Erich Rothacker’s Philosophy of Culture [PDF]
, 2020 Erich Rothacker (1888–1965) was a key figure in early-twentieth-century philosophy in Germany. In this paper, I examine the development of Rothacker’s philosophy of culture from 1907 to 1945.
Steizinger, Johannes
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Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
The ethical problem of Kant's cosmic peace
آداب الكوفة, 2012 There is no hope that man seeks in our world and our time and longs for with passion, more than what he longs for in eternal and cosmic peace, a peace that would liberate the future of humanity from its greatest suffering resulting from the rapid ...
سمير بلكفيف
doaj +2 more sources