Results 71 to 80 of about 17,528,888 (291)

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

A Quest for the Essence of Human Enhancement

Yixue yu zhexue
Human enhancement refers to the practical operation and application of relevant technologies on human beings (including the physiological, cognitive, emotional and willpower dimensions), and thereby extending, replacing or updating all aspects of the ...
Xuan JIANG
doaj   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Predittività genetica e human enhancement: questioni biogiuridiche

European Journal of Privacy Law & Technologies
Il largo ed incisivo impiego delle applicazioni tecnologiche, nei settori più diversi dell’agire umano, produce effetti impattanti e pervasivi sul soggetto e sulle situazioni esistenziali di cui è portatore, e ciò impone l’esigenza di rimodulare la ...
Susanna Cappuccio
doaj   +1 more source

Human enhancement: questioni biogiuridiche

International Journal of Developmental and Educational Psychology. Revista INFAD de Psicología., 2019
Human Enhancement is a modification aimed to improve human’s characteristics and capabilities through scientific or technological interventions in the human body, starting from an ‘integrity condition’ and not from a state of disease. Therefore, we need to value if the enhancement is harmful of the human dignity or if it’s an useful tool to improve the
lidia ricci, mariangela cersosimo, pasquale ricci   +2 more
openaire   +3 more sources

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Reframing Human Enhancement: A Population Health Perspective

Frontiers in Sociology, 2017
The dominant understandings on human enhancement, such as those based on the therapy-enhancement distinction or transhumanist views, have been focused on high technological interventions directly changing biological and physical features of individuals ...
L. Cabrera
semanticscholar   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Human enhancement: from disability to superability [PDF]

Developmental Medicine & Child Neurology, 2019
Video Podcast: https://www.youtube.com/watch?v=GY9YmA2jkow&t ...
openaire   +2 more sources

Political Minimalism and Social Debates: The Case of Human-Enhancement Technologies

Journal of Bioethical Inquiry, 2017
A faulty understanding of the relationship between morality and politics encumbers many contemporary debates on human enhancement. As a result, some ethical reflections on enhancement undervalue its social dimensions, while some social approaches to the ...
J. Rodríguez-Alcázar
semanticscholar   +1 more source