Results 181 to 190 of about 31,425 (209)
Some of the next articles are maybe not open access.
Human epididymis protein 4: Factors of variation
Clinica Chimica Acta, 2015Amongst the newly proposed biomarkers for ovarian cancer, serum human epididymis protein 4 (HE4) shows the greatest potential for clinical use. However, systematic appraisals of its biological characteristics are not available. This study sought to critically revise the available literature on biological and lifestyle factors affecting HE4 ...
Simona Ferraro, Mauro Panteghini
exaly +4 more sources
Expression and biochemical characterization of recombinant human epididymis protein 4
Protein Expression and Purification, 2014Whey acidic proteins (WAP) belong to a large gene family of antibacterial peptides that perform critical immune system functions. The function of human epididymis protein 4 (HE4), a 124-amino acid long polypeptide that has two whey acidic protein four-disulfide core (WFDC) domains, is not well studied. Here, a fusion gene encoding the HE4 protein fused
Ling Hua, Shuai Zhen, Jiyue Cao
exaly +3 more sources
Human epididymis protein 4 in endometrial cancer: A meta-analysis
Clinica Chimica Acta, 2018Serum human epididymis protein 4 (HE4) is a potential marker for endometrial cancer (EC), however, the diagnostic value of HE4 for EC remains controversial. In this study, we performed a meta-analysis to estimate the diagnostic accuracy of serum HE4 for EC.Literature reports of the diagnostic accuracy of serum HE4 for EC were systematically identified ...
Yi Zhong, Tao Su, Xiao-Ming Fan
exaly +3 more sources
Human epididymis protein 4 (HE4) and ovarian cancer prognosis
Gynecologic Oncology, 2012A cohort study was conducted to evaluate whether preoperative plasma HE4 levels could predict the occurrence of death (primary endpoint) and progression (secondary endpoint) in women with ovarian cancer (OC).Between 1998 and 2006, we recruited 136 women newly diagnosed with OC of any FIGO stage at the University Hospital, CHUQ-L'Hôtel-Dieu de Québec ...
Dominique Trudel +2 more
exaly +3 more sources
Human epididymis protein 4 and fetal lung maturity
Journal of Perinatal Medicine, 2021Abstract Objectives To document the maternal and fetal cord blood levels of human epididymis protein 4 (HE-4) in term and preterm newborns in order to investigate the possible physiological role of HE-4 in fetal lung development. Methods
Hande Esra Koca +7 more
openaire +2 more sources
Utility of human epididymis protein 4 in the differential diagnosis of ascites
Clinical Biochemistry, 2023Human epididymal protein 4 (HE4) may be a useful tool in the differential diagnosis of malignant ascites. The aim of this study was to evaluate the diagnostic utility of HE4 for detecting malignant ascites, taking into account the possible false positives identified with adenosine deaminase (ADA), C-reactive protein (CRP), % polynuclear cells (%PMN ...
Silvia Bérgamo +15 more
openaire +2 more sources
Verification of the harmonization of human epididymis protein 4 assays
Clinical Chemistry and Laboratory Medicine (CCLM), 2016Abstract Background: Serum human epididymis protein 4 (HE4) has gained relevance as an ovarian cancer (OC) biomarker and new automated methods have replaced the first released manual EIA by tracing results to it. We verified agreement and bias of automated methods vs.
S. Ferraro +5 more
openaire +2 more sources
Clinical utility of human epididymis protein 4
Critical Reviews in Clinical Laboratory SciencesThis review comprehensively elucidates the current clinical applications of human epididymis protein 4 (HE4) in various systemic diseases. Initially discovered in 1991 and linked to sperm maturation, HE4 has since been recognized for its significant expression in numerous malignant tumors.
Meihua, Qiu +3 more
openaire +2 more sources
The role of human epididymis protein 4 as a biomarker in gynecologic malignancies
Minerva Ginecologica, 2019The serum levels of glycoprotein human epididymis protein 4 (HE4) have been widely investigated in patients with ovarian cancer as a tumor marker to differentiate benign gynecological tumors from ovarian cancers (OC). A few studies demonstrated the promising role of HE4 in endometrial cancer (EC) too.
Francesco, Plotti +11 more
openaire +2 more sources
Clinical Evaluation of Human Epididymis Protein 4 as a Biomarker for Epididymitis
Biomarkers in Medicine, 2012To evaluate HE4 as a potential biomarker for acute epididymitis.HE4 levels in serum were measured in 62 patients with acute epididymitis and 62 age-matched male controls.Both patients with epididymitis and the controls showed median HE4 values of 42 pmol/l (range: 10-560 pmol/l) and 34 pmol/l (range: 2-300 pmol/l), respectively (p = 0.3). Levels of HE4
A, Pilatz +4 more
openaire +2 more sources