Results 1 to 10 of about 2,102 (119)

WAP four-disulfide core domain protein 2 promotes metastasis of human ovarian cancer by regulation of metastasis-associated genes [PDF]

Journal of Ovarian Research, 2017
Background WAP four-disulfide core domain protein 2 (WFDC2) shows a tumor-restricted upregulated pattern of expression in ovarian cancer. Methods In this study, we evaluated the role of WFCD2 in tumor mobility, invasion and metastasis of ovarian cancer ...
Yao Chen, Liping Huang, Suihai Wang, Tiancai Liu, Yingsong Wu, Ji-Liang Li, Ming Li   +6 more
doaj   +9 more sources

WAP four-disulfide core domain protein 2 gene(WFDC2) is a target of estrogen in ovarian cancer cells. [PDF]

J Ovarian Res, 2016
WAP four-disulfide core domain protein 2 (WFDC2) shows a tumor-restricted upregulated pattern of expression in ovarian cancer.We investigated the role of estradiol (E2) on cell growth in estrogen-sensitive or estrogen-insensitive ovarian cancer cell lines.
Chen Y, Wang S, Liu T, Wu Y, Li JL, Li M.   +5 more
europepmc   +12 more sources

Repurposing mebendazole to reprogram oncogenic and tumor-suppressor networks: Multi-cancer insights from ENOX2, MMP2, RASSF1A, WFDC10A and METTL7A. [PDF]

PLoS ONE
BackgroundCancer progression involves coordinated regulation of oncogenes and tumor suppressors. This study explores the interplay of ENOX2 (ecto-NADH oxidase disulfide-thiol exchanger 2), MMP2 (matrix metalloproteinase-2), and regulatory genes Ras ...
Rasha Shaker Aqel, Areej Sami Ismail, Mohamed El-Tanani, Shakta Mani Satyam   +3 more
doaj   +2 more sources

Lack of whey acidic protein (WAP) four-disulfide core domain protease inhibitor 2 (WFDC2) causes neonatal death from respiratory failure in mice

Disease Models & Mechanisms, 2019
Respiratory failure is a life-threatening problem for pre-term and term infants, yet many causes remain unknown. Here, we present evidence that whey acidic protein (WAP) four-disulfide core domain protease inhibitor 2 (Wfdc2), a protease inhibitor ...
Kuniko Nakajima, Michio Ono, Uroš Radović, Selma Dizdarević, Shin-ichi Tomizawa, Kazushige Kuroha, Go Nagamatsu, Ikue Hoshi, Risa Matsunaga, Takayuki Shirakawa, Takeyuki Kurosawa, Yasunari Miyazaki, Masahide Seki, Yutaka Suzuki, Haruhiko Koseki, Masataka Nakamura, Toshio Suda, Kazuyuki Ohbo   +17 more
doaj   +3 more sources

Proteomics for heart failure risk stratification: a systematic review [PDF]

BMC Medicine
Background Heart failure (HF) is a complex clinical syndrome with persistently high mortality. High-throughput proteomic technologies offer new opportunities to improve HF risk stratification, but their contribution remains to be clearly defined.
Kayode O. Kuku, Rebecca Oyetoro, Maryam Hashemian, Alicia A. Livinski, Joseph J. Shearer, Jungnam Joo, Bruce M. Psaty, Daniel Levy, Peter Ganz, Véronique L. Roger   +9 more
doaj   +2 more sources

Akkermansia deficiency and mucin depletion are implicated in intestinal barrier dysfunction as earlier event in the development of inflammation in interleukin-10-deficient mice

Frontiers in Microbiology, 2023
BackgroundDysbiosis and mucin depletion are related with intestinal barrier dysfunction and seems to be an early pathophysiological event in inflammatory bowel disease (IBD).
Beatriz López-Cauce, Beatriz López-Cauce, Beatriz López-Cauce, Marta Puerto, Marta Puerto, Juan José García, Manuel Ponce-Alonso, Federico Becerra-Aparicio, Rosa del Campo, Isabel Peligros, María J. Fernández-Aceñero, Yésica Gómez-Navarro, José M. Lara, José Miranda-Bautista, José Miranda-Bautista, Ignacio Marín-Jiménez, Ignacio Marín-Jiménez, Rafael Bañares, Rafael Bañares, Rafael Bañares, Luis Menchén, Luis Menchén, Luis Menchén   +22 more
doaj   +1 more source

Elevated plasma levels of WAP four-disulfide core domain 2 as a potential prognostic biomarker for various cancers. [PDF]

Front Oncol
Watanabe M, Ieguchi K, Onishi N, Shimizu T, Ohkuma R, Suzuki R, Mura E, Iriguchi N, Ishiguro T, Hirasawa Y, Ikeda G, Shimokawa M, Ariizumi H, Horiike A, Yoshimura K, Tsunoda T, Tsuji M, Kobayashi S, Kiuchi Y, Wada S.   +19 more
europepmc   +2 more sources

Metal exposure from additive manufacturing and its effect on the nasal lavage fluid proteome - a pilot study.

PLoS ONE, 2021
The use of metal additive manufacturing (AM) is steadily increasing and is an emerging concern regarding occupational exposure. In this study, non-invasive sampled nasal lavage fluid (NLF) from the upper airways was collected from metal AM operators at ...
Maria Assenhöj, Liam J Ward, Bijar Ghafouri, Pål Graff, Stefan A Ljunggren   +4 more
doaj   +1 more source

Serum HE4: An Independent Prognostic Factor in Non-Small Cell Lung Cancer. [PDF]

PLoS ONE, 2015
Human epididymis secretory protein 4 (HE4) is a secreted glycosylated protein encoded by the WAP four-disulfide core domain 2 (WFDC2) gene, located on a chromosome 20 segment that is frequently amplified in many cancers.
Pierre-Jean Lamy, Carine Plassot, Jean-Louis Pujol   +2 more
doaj   +1 more source

Identification of CTLA2A, DEFB29, WFDC15B, SERPINA1F and MUP19 as Novel Tissue-Specific Secretory Factors in Mouse. [PDF]

PLoS ONE, 2015
Secretory factors in animals play an important role in communication between different cells, tissues and organs. Especially, the secretory factors with specific expression in one tissue may reflect important functions and unique status of that tissue in
Jibin Zhang, Jinsoo Ahn, Yeunsu Suh, Seongsoo Hwang, Michael E Davis, Kichoon Lee   +5 more
doaj   +1 more source