Results 21 to 30 of about 2,121 (136)

A role for whey acidic protein four-disulfide-core 12 (WFDC12) in the regulation of the inflammatory response in the lung [PDF]

, 2015
Introduction: Secretory leucocyte protease inhibitor and elafin are members of the whey acidic protein (WAP), or WAP four disulfide-core (WFDC), family of proteins and have multiple contributions to innate defence including inhibition of neutrophil ...
Camper, Nicolas, Elborn, J Stuart, Glasgow, Arlene M A, Hamid, Umar, Hegarty, Shauna, Lundy, Fionnuala T, McAuley, Danny F, McLean, Denise T, McNally, Paul, O'Kane, Cecilia, Parekh, Dhruv, Scott, Aaron, Small, Donna M, Taggart, Clifford C, Weldon, Sinéad   +14 more
core   +1 more source

Characterisation of urinary WFDC12 in small nocturnal basal primates, mouse lemurs (Microcebus spp.) [PDF]

, 2017
Mouse lemurs are basal primates that rely on chemo- and acoustic signalling for social interactions in their dispersed social systems. We examined the urinary protein content of two mouse lemurs species, within and outside the breeding season, to assess ...
Beynon, RJ, Davidson, AJ, Gomez-Baena, G, Hurst, JL, Loxley, G, Mundy, NI, Radespiel, U, Unsworth, J, Zimmerman, E   +8 more
core   +1 more source

Microarray profiling of progesterone-regulated endometrial genes during the rhesus monkey secretory phase

Reproductive Biology and Endocrinology, 2004
Background In the endometrium the steroid hormone progesterone (P), acting through its nuclear receptors, regulates the expression of specific target genes and gene networks required for endometrial maturation. Proper endometrial maturation is considered
Okulicz William C, Ace Christopher I
doaj   +1 more source

HE4 (WFDC2) Promotes Tumor Growth in Endometrial Cancer Cell Lines [PDF]

, 2013
HE4, also known as WFDC2, is a useful biomarker for ovarian cancer when either used alone or in combination with CA125. HE4 is also overexpressed in endometrial cancer (EC), but its function in cancer cells is not clear. In this study, we investigate the
Broaddus, Russell, Chen, Dong, Chen, Haibin, Dowdy, Sean, Drapkin, Ronny I., Jiang, Shi-Wen, Klatt, Edward, Li, Jinping, Mariani, Andrea, Podratz, Karl   +9 more
core   +2 more sources

Identification of Cell Surface Proteins as Potential Immunotherapy Targets in 12 Pediatric Cancers [PDF]

, 2012
Technological advances now allow us to rapidly produce CARs and other antibody-derived therapeutics targeting cell surface receptors. To maximize the potential of these new technologies, relevant extracellular targets must be identified.
Crystal L. Mackall, James J. Yang, Javed Khan, Jun S. Wei, Rimas J. Orentas, Xinyu Wen   +5 more
core   +2 more sources

An in vitro model of murine middle ear epithelium. [PDF]

, 2016
Otitis media (OM) or middle ear inflammation is the most common pediatric disease and leads to significant morbidity. Although understanding of underlying disease mechanisms is hampered by complex pathophysiology it is clear that epithelial abnormalities
Admyre, Amesara, Atherton, Bakaletz, Barnes, Bartlett, Bernstein, Bingle, Butler, Casey, Cash, Choi, Choi, Chun, Clarke, Cody, Davidson, Davies, Gao, Gaschler, Hendrixson, Herman, Horani, Horani, Juhn, Kapsogeorgou, Keller, Kerschner, Kesimer, Kim, Kondo, Lechner, Lim, Lim, Lim, Lim, Liu, Loonen, Matsui, Mcguire, Moon, Moon, Musa, Nakamura, Pillai, Portier, Preciado, Preciado, Roy, Rye, Rye, Schachern, Schousboe, Straetemans, Takeno, Thompson, Toyama, Tsuchiya, Ueyama, Vaishnava, Val, Valadi, Van Blitterswijk, Van Niel, van Rozendaal, Vladar, Woo, Woodfield, Woodworth, Wright, Wu, Yamaya, You, You   +73 more
core   +3 more sources

S-nitrosation of proteins relevant to Alzheimer's disease during early stages of neurodegeneration [PDF]

, 2016
Protein S-nitrosation (SNO-protein), the nitric oxide-mediated posttranslational modification of cysteine thiols, is an important regulatory mechanism of protein function in both physiological and pathological pathways.
Bhat, Vadiraja B., Nott, Alexi, Ravindra, Kodihalli C., Seneviratnea, Uthpala, Tannenbaum, Steven R, Tsai, Li-Huei, Wishnok, John S   +6 more
core   +1 more source

HE4 in the differential diagnosis of ovarian masses [PDF]

, 2015
Ovarian masses, a common finding among pre- and post-menopausal women, can be benign or malignant. Ovarian cancer is the leading cause of death from gynecologic malignancy among women living in industrialized countries.
ANASTASI, Emanuela, ANGELONI, Antonio, Flavia Longo, MANGANARO, Lucia, PORPORA, Maria Grazia, Teresa Granato   +5 more
core   +1 more source

WFDC1 expression identifies memory CD4 T- lymphocytes rendered vulnerable to cell-cell HIV-1 transfer by promoting intercellular adhesive junctions [PDF]

, 2011
Background: Elucidating mechanisms that promote HIV-1 transfer between CD4(+) T-lymphocytes and their subsequent loss is of importance to HIV-1 pathogenesis.
Annapurna Vyakarnam, Georgina Thorborn, James L Reading, Raymond A Alvarez, Shalini Reddy   +4 more
core   +1 more source

Biomarker-Guided Versus Guideline-Based Treatment of Patients With Heart Failure:Results From BIOSTAT-CHF [PDF]

, 2018
BACKGROUND: Heart failure guidelines recommend up-titration of angiotensin-converting enzyme (ACE) inhibitor/angiotensin receptor blockers (ARBs), beta-blockers, and mineralocorticoid receptor antagonists (MRAs) to doses used in randomized clinical ...
Anker, Stefan D., Cleland, John G. F., Demissei, Biniyam, Dickstein, Kenneth, Filippatos, Gerasimos S., Hillege, Hans L., Lang, Chim, Metra, Marco, Ng, Leong L., Ouwerkerk, Wouter, Ponikowski, Piotr, Samani, Nilesh J., ter Maaten, Jozine M., van der Harst, Pim, van Veldhuisen, Dirk J., Voors, Adriaan A., Zannad, Faiez, Zwinderman, Aeilko H.   +17 more
core   +4 more sources