Next-generation proteomics improves lung cancer risk prediction. [PDF]
Mol OncolThis is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Bhardwaj M +4 more
europepmc +2 more sources
SORBS2: A Molecular Nexus in Multisystem Diseases Through Scaffold-Mediated Regulation. [PDF]
J Cell Mol MedABSTRACT Sorbin and SH3 Domain Containing 2 (SORBS2), a multifunctional scaffold protein harbouring Sorbin homology (SoHo) and Src homology 3 (SH3) domains, serves as a molecular hub in human diseases by integrating cytoskeletal remodelling, signal transduction and RNA metabolic regulation. This study systematically analyses SORBS2's molecular features,
Jia Q, Zhang Y.
europepmc +2 more sources
BMC Cancer, 2023 Background Early diagnosis of lung adenocarcinoma (LUAD), one of the most common types of lung cancer, is very important to improve the prognosis of patients. The current methods can’t meet the requirements of early diagnosis. There is a pressing need to
Junfeng Li +16 more
doaj +1 more source
The Role of Whey Acidic Protein Four-Disulfide-Core Proteins in Respiratory Health and Disease [PDF]
, 2016 Members of the whey acidic protein (WAP) or WAP four-disulfide-core (WFDC) family of proteins are a relatively under-explored family of low molecular weight proteins. The two most prominent WFDC proteins, secretory leukocyte protease inhibitor (SLPI) and
Doherty, Declan F. +4 more
core +1 more source
Comparison in gene expression of secretory human endometrium using laser microdissection
Reproductive Biology and Endocrinology, 2004 Background The endometrium prepares for implantation under the control of steroid hormones. It has been suggested that there are complicated interactions between the epithelium and stroma in the endometrium during menstrual cycle.
Aida Tadateru +5 more
doaj +1 more source
Oncology Reports, 2012 The WAP four-disulfide core domain protein 2 (WFDC2) is frequently overexpressed in epithelial ovarian cancer cells and has been proposed as a potential biomarker. The biological function of WFDC2 in tumor progression remains unclear.
Yao, Chen +6 more
openaire +3 more sources
Anosmin-1 modulates fibroblast growth factor receptor 1 signaling in human gonadotropin-releasing hormone olfactory neuroblasts through a heparan sulfate-dependent mechanism [PDF]
, 2004 Defects of either anosmin-1 or fibroblast growth factor receptor 1 (FGFR1) are known to underlie hereditary Kallmann's syndrome (KS), a human disorder of olfactory and gonadotropin-releasing hormone (GnRH) neuronal ontogeny.
Bouloux, PM +8 more
core +1 more source
Cardioprotective factors against myocardial infarction selected in vivo from an AAV secretome library [PDF]
, 2022 Therapies for patients with myocardial infarction and heart failure are urgently needed, in light of the breadth of these conditions and lack of curative treatments.
Bortolotti, Francesca +13 more
core +1 more source
HE4 Transcription- and Splice Variants-Specific Expression in Endometrial Cancer and Correlation with Patient Survival [PDF]
, 2013 We investigated the HE4 variant-specific expression patterns in various normal tissues as well as in normal and malignant endometrial tissues. The relationships between mRNA variants and age, body weight, or survival are analyzed. ICAT-labeled normal and
Attewell, John +9 more
core +2 more sources
Antimicrobial proteins : from old proteins, new tricks [PDF]
, 2015 This review describes the main types of antimicrobial peptides (AMPs) synthesised by crustaceans, primarily those identified in shrimp, crayfish, crab and lobster.
Dyrynda, Elisabeth, Smith, Val
core +2 more sources