Results 171 to 180 of about 3,138,101 (337)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Author Correction: New perspectives on Neanderthal dispersal and turnover from Stajnia Cave (Poland)

Scientific Reports, 2022
Andrea Picin, Mateja Hajdinjak, Wioletta Nowaczewska, Stefano Benazzi, Mikołaj Urbanowski, Adrian Marciszak, Helen Fewlass, Marjolein D. Bosch, Paweł Socha, Krzysztof Stefaniak, Marcin Żarski, Andrzej Wiśniewski, Jean‑Jacques Hublin, Adam Nadachowski, Sahra Talamo   +14 more
doaj   +1 more source

The planetary diet: a nutritional utopia in conflict with human evolution. [PDF]

Nutr Metab (Lond)
Spinosa JP, Lee DC, Duraj T, Seyfried TN.   +3 more
europepmc   +1 more source

Dental calculus: A repository of bioinformation indicating diseases and human evolution. [PDF]

Front Cell Infect Microbiol, 2022
Li Q, Luo K, Su Z, Huang F, Wu Y, Zhou F, Li Y, Peng X, Li J, Ren B.   +9 more
europepmc   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Global impact of micronutrients in modern human evolution. [PDF]

Am J Hum Genet
Rees J, Castellano S, Andrés AM.
europepmc   +1 more source

Leveraging our common African origins to understand human evolution and health. [PDF]

Cell Genom, 2023
Wonkam A, Adeyemo A.
europepmc   +1 more source

Molecular Surveillance Reveals F-Gene Mutations and Constrained G-Gene Evolution in Human Respiratory Syncytial Virus: Implications for Vaccine Efficacy in Saudi Arabia [PDF]

Mohamed A. Farrag, Ibrahim M. Aziz, Abdulaziz Almuqrin, Noorah A. Alkubaisi, Reem M. Aljowaie, Asma N. Alsaleh, Fars K. Alanazi, Adel A. Abdulmanea, Fahad N. Almajhdi   +8 more
openalex   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Paleoparasitology and human evolution.

Trop Parasitol, 2023
Parija SC.
europepmc   +1 more source