Results 131 to 140 of about 26,756,178 (360)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Beyond composite scores in chronotype assessment: item-level predictive patterns in the Morningness–Eveningness Questionnaire

Scientific Reports
Chronotype represents individual differences in circadian preferences that influence sleep-wake patterns, cognitive performance, and clinical outcomes across the lifespan.
Yannick A. Metzler, Hannah M. Schade, Michael A. Nitsche, Edmund Wascher, Stephan Getzmann, Patrick D. Gajewski, Lorena Melo   +6 more
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Changes of cognitive functions and proinflammatory cytokines across the lifespan in latent Toxoplasma gondii infection

Brain, Behavior, & Immunity - Health
Background: Recent findings showed serious consequences of latent T. gondii infection on the central nervous system, leading to psychiatric, immunological and cognitive impairments.
Patrick D. Gajewski, Peter Bröde, Maren Claus, Klaus Golka, Jan G. Hengstler, Jörg Reinders, Carsten Watzl, Edmund Wascher, Stephan Getzmann   +8 more
doaj   +1 more source

Induction of pluripotent stem cells from adult human fibroblasts by defined factors.

Cell, 2007
Kazutoshi Takahashi, K. Tanabe, M. Ohnuki, Megumi Narita, T. Ichisaka, K. Tomoda, S. Yamanaka   +6 more
semanticscholar   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Effect of road design on hazard anticipation behavior among motorcyclists during merging in traffic

, 2019
Road accident is one of the top contributing factors for human fatalities around the world. Among the road users, motorcyclist is considered one of the most vulnerable road user group that contributed to a large number of road crashes.
JawatanKuasa Kerja PSM Human Factors and Ergonomics Society Malaysia
core  

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Patient-Centric Design of the Lonapegsomatropin Auto-Injector for Growth Hormone Deficiency: Usability Validation of Safe and Effective Use

Medical Devices: Evidence and Research
Michael Lau,1 Paul Erik Fabricius,2 Nils Berg Madsen,3 Henrik Egesborg,3 Josephine Jensen3 1Human Factors Engineering, Insight by Nemera, Chicago, IL, USA; 2Industrial Design and HFE, Phillips-Medisize A/S, Struer, Denmark; 3Device Development, Ascendis ...
Lau M, Fabricius PE, Madsen NB, Egesborg H, Jensen J   +4 more
doaj