Results 141 to 150 of about 18,923,181 (308)

Inhibition of dipeptidyl peptidase 7 impairs lysophagy in LLOMe‐treated HepG2 cells

FEBS Letters, EarlyView.
DPP7 inhibition delays ubiquitin‐dependent lysophagy by attenuating ubiquitin accumulation and the recruitment of SQSTM1 and LC3 to damaged lysosomes, resulting in delayed clearance of damaged lysosomes and impaired restoration of lysosomal homeostasis. Created using FigureLabs (Certificate ID: FL‐PUB‐20260922‐Z99XNX).
Na Yeon Park, Inho Kwon, Yong Hwan Kim, Ji‐Eun Bae, Joon Bum Kim, Seong Hyun Kim, Sungho Maeng, Doo Sin Jo, Dong‐Hyung Cho   +8 more
wiley   +1 more source

Human Factors and Device Engineering in OTC Intranasal Drug Delivery: GentleMist Technology™. [PDF]

Pharmaceutics
Alas-Pineda C, Pavón-Varela DJ, Gaitán-Zambrano K, Coto-Tejeda C, Medina-Mejía J, Andrews Interiano N, Ferrer G.   +6 more
europepmc   +1 more source

DNA ligase LigE increases bacterial transformation with damaged extracellular DNA

FEBS Letters, EarlyView.
The DNA ligase LigE from the naturally competent Gram‐negative bacterium Neisseria gonorrhoaea increases transformation with cut extracellular DNA. This process is ATP‐dependent and relies on the catalytic activity of LigE; it also requires that LigE contains an intact periplasmic localisation sequence, indicating that ligE functions in the periplasm ...
Jolyn Pan, Avi Singh, Shrawani Weralupe Gamladdalage, Joanna Hicks, Adele Williamson   +4 more
wiley   +1 more source

Human factors analysis of automotive adaptive equipment for disabled drivers /

, 1980
"Contract no. DOT HS-8-02049.""DOT HS-805 726.""October 1980.""Texas Transportation Institute, Human Factors Div., the Texas A&M University System.""Final report."Cover title.Includes bibliographical references.Mode of access ...
Texas Transportation Institute. Human Factors Division., United States. National Highway Traffic Safety Administration., Koppa, Rodger J.   +2 more
core  

EVALUATING THE EFFECTS OF AUTOMATION ON THE HUMAN OPERATOR PERSPECTIVES

, 1989
Czaja, S J, HUMAN FACTORS SOC, Kleiner, B M, Drury, C G, Sharit, J   +4 more
core   +2 more sources

Human factors methods for designing safe health information technology: what do the experts think? [PDF]

J Am Med Inform Assoc
Awad S, Begg R, Loveday T, Baillie A, Baysari MT.   +4 more
europepmc   +1 more source

Going viral − Virus‐targeting nanobodies for research, diagnostics and therapy

FEBS Letters, EarlyView.
The increasing prevalence of viral diseases represents a major threat for global human health. Nanobodies, small binding fragments derived from camelid heavy‐chain antibodies, offer versatile tools for viral research, diagnostics, and antiviral therapy.
Domenic Ebert, Ulrich Rothbauer
wiley   +1 more source

Evaluation of CTCLS series traffic signal load switches in the field : bulb life determinations, and development of a group relamping model

, 2003
"July 2003."; Includes bibliographical references (leaves 69-70).; Final report.; Performed by Ohio Research Institute for Transportation and the Environment, Human Factors and Ergonomics Laboratory in cooperation with the Federal Highway Administration,
Zwahlen, Helmut T., Ohio Research Institute for Transportation and the Environment. Human Factors and Ergonomics Laboratory.   +1 more
core  

Is "Just-in-Case" catheterisation inappropriate or system-driven? A human factors perspective - Authors' reply. [PDF]

Lancet Reg Health Eur
Drugeon B, Mimoz O.
europepmc   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source