Results 271 to 280 of about 9,687,585 (343)

Using human factors methods to mitigate bias in artificial intelligence-based clinical decision support. [PDF]

J Am Med Inform Assoc
Militello LG, Diiulio J, Wilson DL, Nguyen KA, Harle CA, Gellad W, Lo-Ciganic WH.   +6 more
europepmc   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Extending care beyond the clinic: integrating patient-reported outcomes in chronic pain management through human factors engineering. [PDF]

Front Health Serv
Kazi S, Littlejohn R, Smith KM, Busog DN, Blumenthal J, Mathur S, McGill Z, DeBold D, Hettinger AZ, Miller KE.   +9 more
europepmc   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Design and context of use of postpartum haemorrhage kits in the UK: a qualitative study combining human factors and social science analysis

Woodward M, Powell A, Dixon-Woods M, Burt J, Winter C, Lattey K, Draycott TJ, PPH Kits Contributor Group, van der Scheer JW.   +8 more
europepmc   +1 more source

Workshop Proceedings: Space Human Factors, Volume 1 [PDF]

Cron, A. C., Montemerio, M. D.
core   +1 more source

Impact of Natural and Human Factors on Dryland Vegetation in Eurasia from 2003 to 2022. [PDF]

Plants (Basel)
Liu J, Zhao J, He J, Zhang P, Yi F, Yue C, Wang L, Mei D, Teng S, Duan L, Sun N, Hu Z.   +11 more
europepmc   +1 more source

Integrating Human Factors and Semantic Mark-ups in Adaptive Interactive Systems

, 2014
Marios Belk, Panagiotis Germanakos, Efi Papatheocharous, Panayiotis C. Andreou, George Samaras   +4 more
openalex   +1 more source

Workshop Proceedings: Space Human Factors, Volume 2 [PDF]

Cron, A. C., Montemerio, M. D.
core   +1 more source