Results 91 to 100 of about 8,808,045 (405)

Human Papilloma Virus (HPV) and Fertilization: A Mini Review

Medicina, 2018
Human papilloma virus (HPV) is one of the most prevalent viral sexually transmitted diseases. The ability of HPV to induce malignancy in the anogenital tract and stomato-pharyngeal cavity is well documented.
Konstantinos Zacharis, Christina I. Messini, George Anifandis, George Koukoulis, Maria Satra, Alexandros Daponte   +5 more
doaj   +1 more source

Mitochondrial Replacement Techniques and Mexico’s Rule of Law: On the Legality of the First Maternal Spindle Transfer Case [PDF]

, 2017
News about the first baby born after a mitochondrial replacement technique (MRT; specifically maternal spindle transfer) broke on September 27, 2016 and, in a matter of hours, went global.
Palacios-González, César
core  

5’‐Methylthioadenosine Metabolic Reprogramming Drives H3K79 Monomethylation‐Mediated PAK2 Upregulation to Promote Cadmium‐Induced Breast Cancer Progression by Impairing Autophagic Flux

Advanced Science, EarlyView.
Cadmium, a carcinogenic heavy metal, drives breast cancer progression via metabolic reprogramming and autophagic flux disruption. Multi‐omics revealed cadmium‐induced 5'‐methylthioadenosine depletion activates DOT1L‐mediated H3K79me1 at PAK2 promoter, upregulating PAK2 to block autophagy and driving malignancy. Clinically, 5'‐methylthioadenosine levels
Jingdian Li, Ping Deng, Tengfei Fan, Yuchen Qu, Miduo Tan, Yidan Liang, Peng Gao, Yongchun Peng, Mingke Qin, Sheng Jie, Rongrong Hao, Liting Wang, Lei Zhang, Chunhai Chen, Mindi He, Qinlong Ma, Yan Luo, Li Tian, Jia Xie, Mengyan Chen, Rui Tian, Min Li, Zhengping Yu, Zhou Zhou, Huifeng Pi   +24 more
wiley   +1 more source

Improving soil pH prediction and mapping using anthropogenic variables and machine learning models

Geocarto International
This study evaluates the impact of anthropogenic activities on soil pH prediction in China's Huang-Huai-Hai Plain using four machine learning models (RF, LightGBM, XGBoost, SVM).
Daocheng Li, Erlong Xiao, Yingxin Xia, Xingyu Liang, Mengxin Guo, Lixin Ning, Jun Yan   +6 more
doaj   +1 more source

The unknown face of in vitro fertilization

Medicina y Ética, 2021
The purpose of this article is to show the unknown face of artificial human reproduction methods. Generally, human fertilization cli- nics only show the most attractive face of in vitro fertilization: the newborn.
José María Pardo Sáenz
doaj  

MAIA, Fc receptor-like 3, supersedes JUNO as IZUMO1 receptor during human fertilization. [PDF]

Sci Adv, 2022
Vondrakova J, Frolikova M, Ded L, Cerny J, Postlerova P, Palenikova V, Simonik O, Nahacka Z, Basus K, Valaskova E, Machan R, Pacey A, Holubcova Z, Koubek P, Ezrova Z, Park S, Liu R, Partha R, Clark N, Neuzil J, Ikawa M, Erickson K, Lam KS, Moore H, Komrskova K.   +24 more
europepmc   +1 more source

Dysfunctional Decidual CD4+T Cells Induce Recurrent Pregnancy Loss via Palmitoylation‐Dependent Tim‐3 Lysosomal Sorting and Degradation

Advanced Science, EarlyView.
Dysfunctional decidual CD4+T cells induce recurrent pregnancy loss via palmitoylation‐dependent Tim‐3 lysosomal sorting and degradation. The integrated bioinformatics, proteomic, functional and model studies elucidate that Tim‐3 is palmitoylated by ZDHHC3 at Cys9. Sortilin bound to and directed palmitoylated Tim‐3 toward lysosome degradation, resulting
Liyuan Cui, Xinhang Meng, Yujie Luo, Jinfeng Qian, Fengrun Sun, Mingke Qiu, Songcun Wang   +6 more
wiley   +1 more source

A Novel Cultivation System for Germ Cell Proliferation and Sustaining Whole Testicular Niche

Advanced Science, EarlyView.
A hydrogel microneedle‐based system enables whole testicular cultivation, supporting spermatogonial proliferation and enhancing spermatogenesis in vitro. This ‘whole testicular spermatogonia pool’ (WTSP) significantly increases spermatid production and fertility potential in mice. This system also promotes spermatogonial expansion in human fetal testes,
Yu Xia, Xiaoxuan Zhang, Bohang Zhang, Minhui Lu, Qing Cheng, Li Liu, Lifang Shi, Yiqiang Cui, Dingdong Chen, Laihua Li, Xuejiang Guo, Jingtao Guo, Jiahao Sha, Yuanjin Zhao, Yan Yuan   +14 more
wiley   +1 more source

Cationic Peptoids for Systemic In Vivo Cartilage‐Targeting

Advanced Science, EarlyView.
Systemically‐dosed Cy5‐labeled cationic peptoid probe (NlysO)7 (yellow) binds to the cartilage's glycosaminoglycan content in vivo across the entire body of a neonatal mouse imaged by light sheet fluorescence microscopy, revealing fluorescence uptake in generic cartilage as well as the developing and ossifying bones.
Chaonan Zhang, Rongmao Qiu, Yongjie Huang, Yinghua Liu, Kui Huang, Suwen Zhao, Yang Li   +6 more
wiley   +1 more source

A spontaneous increase in intracellular Ca2+ in metaphase II human oocytes in vitro can be prevented by drugs targeting ATP-sensitive K+ channels [PDF]

, 2015
STUDY QUESTION: Could drugs targeting ATP-sensitive K+ (KATP) channels prevent any spontaneous increase in intracellular Ca2+ that may occur in human metaphase II (MII) oocytes under in vitro conditions?
Barratt, Christopher L. R., Barratt, Evelyn, Brown, Sean G., Dasai, Navin, Drew, Ellen, Fernandes, Gonçalo, Gall, Mandy, Jovanović, Aleksandar, Kozlova, Natalia, Madamidola, Oladipo A., Martins da Silva, Sarah J., Milne, Alison M., Mojadadi, Albaraa, Whalley, Katherine M.   +13 more
core   +5 more sources