Results 221 to 230 of about 10,048,978 (405)
Embryonic Determination of Brain Programming Asymmetry - A Neglected Element in Twin-Study Genetics of Human Mental Development [PDF]
, 1976 Charles E. Boklage
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Using human genetics to understand the epidemiological association between neuroticism and lung cancer. [PDF]
Transl Lung Cancer ResWu D +10 more
europepmc +1 more source
Future prospects for human genetics and genomics in drug discovery. [PDF]
Curr Opin Struct Biol, 2023 Ghoussaini M, Nelson MR, Dunham I.
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Molecular Oncology, EarlyView.Loss of primary cilia in endothelial cells promotes EndMT and vascular abnormalities in the ovarian tumor microenvironment through EphA2 activation. Using human samples, in vitro models, and endothelial‐specific Kif3a‐knockout mice, we show that primary cilia loss drives the acquisition of cancer‐associated fibroblast‐like phenotypes, thereby ...
Jin Gu Cho +11 more
wiley +1 more source
Human genetics of metabolic dysfunction-associated steatotic liver disease: from variants to cause to precision treatment. [PDF]
J Clin InvestChen VL +7 more
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Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma
Molecular Oncology, EarlyView.GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski +19 more
wiley +1 more source
Application of Human Genetics to Prioritize Coagulation Cascade Protein Targets for Ischemic Stroke Prevention. [PDF]
StrokeDaghlas I, Karhunen V, Kim AS, Gill D.
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