Results 251 to 260 of about 10,781,581 (397)

Glossary of Bioinformatics Terms [PDF]

, 2015
National Human Genome Research Institute
core   +1 more source

Pharmacological effects of osimertinib on a chicken chorioallantoic membrane xenograft model with the EGFR exon‐19‐deleted advanced NSCLC mutation

FEBS Open Bio, EarlyView.
Osimertinib reduces angiogenesis and PDL1 expression in in ovo tumors, transforming them into ‘cold tumors’ with lower immune activity. Anatomopathological and transcriptomic analyses highlight its therapeutic impact on tumor biology. This study underscores osimertinib's potential to reshape the tumor microenvironment and provides insights into its ...
David Barthélémy, Arnaud Vigneron, Xavier Rousset, Jérome Guitton, Emmanuel Grolleau, Margaux Raffin, Julie Balandier, Gaëlle Lescuyer, Mathilde Bardou, Florence Geiguer, Sébastien Couraud, Claire Bardel, Jean Viallet, Nazim Benzerdjeb, Léa Payen   +14 more
wiley   +1 more source

The human genome encodes a multitude of novel miRNAs. [PDF]

Nucleic Acids Res
Gao F, Wang F, Chen Y, Deng B, Yang F, Cao H, Chen J, Chen H, Qi F, Kapranov P.   +9 more
europepmc   +1 more source

Separation of the plus and minus strands of cytoplasmic polyhedrosis virus and human reovirus double-stranded genome RNAs by gel electrophoresis [PDF]

, 1981
Robert E. Smith, Maureen A. Morgan, Yasuhiro Furuichi   +2 more
openalex   +1 more source

Tryptophan‐sensing receptor GPR142 expression levels are directly regulated by proinflammatory cytokines in ghrelin‐producing cells

FEBS Open Bio, EarlyView.
GPR142, a tryptophan‐sensing receptor, stimulates gastrointestinal hormones like ghrelin and is linked to inflammation regulation. Proinflammatory cytokines suppress ghrelin production, while tryptophan levels decrease via IDO1 activation. Our findings reveal that proinflammatory cytokines directly regulate GPR142 expression in ghrelin‐producing cells,
Yoko Ueda, Hiroshi Iwakura, Takuya Ensho, Mika Bando‐Shimizu, Asako Doi, Norihiko Matsutani, Shuhei Morita, Hidefumi Inaba, Hiroyuki Ariyasu, Naoki Fukuda, Keiji Hayata, Toshiyasu Ojima, Masahiro Nishi, Taka‐aki Matsuoka, Hiroki Yamaue, Takashi Akamizu   +15 more
wiley   +1 more source

Integration of therapeutic cargo into the human genome with programmable type V-K CAST. [PDF]

Nat Commun
Liu J, Aliaga Goltsman DS, Alexander LM, Khayi KK, Hong JH, Dunham DT, Romano CA, Temoche-Diaz MM, Chadha S, Fregoso Ocampo R, Oki-O'Connell J, Janson OP, Turcios K, Gonzalez-Osorio L, Muysson J, Rahman J, Laperriere SM, Devoto AE, Castelle CJ, Butterfield CN, Cost GJ, Brown CT, Thomas BC.   +22 more
europepmc   +1 more source

The human genome as the common heritage of humanity. [PDF]

Front Genet, 2023
Kabata F, Thaldar D.
europepmc   +1 more source

Japanese plans to sequence human genome [PDF]

, 1987
David Swinbanks
openalex   +1 more source

A potential tumor suppressor role of PLK2 in glioblastoma

FEBS Open Bio, EarlyView.
PLK2 was consistently downregulated in GBM tissues. Overexpression of PLK2 in GBM cell lines U87MG and U251 reduced their tumorigenic potential and enhanced cell cycle arrest and apoptosis. Suggesting that PLK2 overexpression could potentially be leveraged as a therapeutic strategy to inhibit tumor progression and enhance apoptosis, providing new ...
Xiangping Xia, Peirui Wang, Hua Xiao, Qishan Ran, Yan Li, Shengtao Yao   +5 more
wiley   +1 more source

Ribosomal DNA arrays are the most H-DNA rich element in the human genome. [PDF]

NAR Genom Bioinform
Chantzi N, Chan CSY, Patsakis M, Nayak A, Montgomery A, Mouratidis I, Georgakopoulos-Soares I.   +6 more
europepmc   +1 more source