Results 261 to 270 of about 11,305,394 (400)

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

Minimal repeats are ubiquitous sites of crossover and recombination across the human genome. [PDF]

BMC Genomics
Ohadi M, Tajeddin N, Bayat H, Annear DJ, Maddi AMA, Khorshid HRK, Kavousi K, Delbari A, Nikkhah A, Arabfard M.   +9 more
europepmc   +1 more source

Potential etiologic and functional implications of genome-wide association loci for human diseases and traits

Proceedings of the National Academy of Sciences of the United States of America, 2009
L. Hindorff, P. Sethupathy, Heather Junkins, E. Ramos, Jayashri P. Mehta, F. Collins, T. Manolio   +6 more
semanticscholar   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Heritable human genome editing and the politics of law: the South African case study. [PDF]

J Law Biosci
Thaldar D, Soni S, Prinsen L, Mnyandu N, Botes M, Kinderlerer J.   +5 more
europepmc   +1 more source

Human Genome [PDF]

, 2020
openaire   +1 more source

Characterizing the Major Structural Variant Alleles of the Human Genome

Cell, 2019
P. Audano, Arvis Sulovari, Tina A. Graves-Lindsay, Stuart Cantsilieris, Melanie Sorensen, AnneMarie E Welch, Max L. Dougherty, Bradley J. Nelson, Ankeeta Shah, S. Dutcher, W. Warren, V. Magrini, S. McGrath, Yang I. Li, R. Wilson, E. Eichler   +15 more
semanticscholar   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

hDNApipe: streamlining human genome analysis and interpretation with an intuitive and user-friendly interface. [PDF]

NAR Genom Bioinform
Zhang Y, Wu Q, Zhou Y, Cheng Q, Jin T.
europepmc   +1 more source

Genome-wide DNA promoter methylation and transcriptome analysis in human adipose tissue unravels novel candidate genes for obesity

, 2016
Maria Keller, Lydia Hopp, Xuanshi Liu, Tobias Wohland, Kerstin Rohde, Raffaella Cancello, Matthias Klös, Karl Bacos, Matthias Kern, Fabian Eichelmann, Arne Dietrich, Michael P. Schön, Daniel Gärtner, Tobias Lohmann, Miriam Dreßler, Michael Stümvoll, Péter Kovács, Anna-Maria DiBlasio, Charlotte Ling, Hans Binder, Matthias Blüher, Yvonne Böttcher   +21 more
openalex   +1 more source