Results 311 to 320 of about 10,071,580 (356)
Minimal residual disease (MRD) leads to cancer relapse and poor survival in ovarian cancer. The lack of representative 3D models limits therapy development. The microfluidics‐based high throughput 3D microtumor platform described here generates clinically‐relevant MRD models. The 3D microtumors recapitulate the molecular signatures of MRD from patients.
Xingyun Yang+14 more
wiley +1 more source
Recent Developments in the Regulation of Heritable Human Genome Editing. [PDF]
Soni S.
europepmc +1 more source
Recent Applications of Mesoporous Silica Nanoparticles in Gene Therapy
The review summarizes the synthesis of mesoporous silica nanoparticles (MSNs) with modifiable surface properties, functionalization strategies, mechanism of therapeutic payload release, and current applications in gene therapy, focusing on their capabilities in the targeted delivery of therapeutic nucleic acids, CRISPR‐Cas systems, and other genetic ...
Tamanna Binte Huq+4 more
wiley +1 more source
Harnessing Nanohybridized Niclosamide for Precision Mpox Therapeutics
This study investigates the potential of nanohybridized niclosamide as a therapeutic agent for Mpox, focusing on enhanced bioavailability, improved antiviral efficacy, and controlled drug release achieved through nanoengineering. The research emphasizes significant advancements in formulation strategies, mechanistic insights, and therapeutic outcomes ...
N. Sanoj Rejinold+2 more
wiley +1 more source
Editorial: The impact of the human genome on interindividual variability in drug response. [PDF]
Kassogue Y, Fricke-Galindo I.
europepmc +1 more source
Negative‐ and positive‐staining TEM is essential for rapid nanometer‐resolution characterization of organic specimens ranging from nanoparticles to cells. Uranyl salts are widely used negative‐/positive‐stains but are radioactive and highly toxic to users and the environment.
Vera M. Kissling+4 more
wiley +1 more source
P618: Misuse of opportunistic screening highlights shortcomings in clinical ascertainment
Julie Sapp+3 more
doaj
A wireless cortical surface implant employing graphene electrode arrays diagnoses and alleviates Parkinson's disease symptoms in freely moving animals. The device continuously monitors cortical activity and delivers targeted stimulation, restoring beta–gamma and delta oscillations.
Hongseong Shin+15 more
wiley +1 more source
Context-adjusted proportion of singletons (CAPS): a novel metric for assessing negative selection in the human genome. [PDF]
Gudkov M, Thibaut L, Giannoulatou E.
europepmc +1 more source
This study develops itaconate‐based polymer microparticles (IA‐MPs) for macrophage‐targeted intracellular delivery, overcoming the limitations of traditional itaconate administration. IA‐MPs achieve controlled release through phagocytosis, reducing pro‐inflammatory cytokine expression and reprogramming macrophage metabolism toward glycolysis.
Kaitlyn E. Woodworth+10 more
wiley +1 more source