Results 331 to 340 of about 11,305,394 (400)

Full-resolution HLA and KIR gene annotations for human genome assemblies. [PDF]

Genome Res
Zhou Y, Song L, Li H.
europepmc   +1 more source

Next‐Generation Bio‐Reducible Lipids Enable Enhanced Vaccine Efficacy in Malaria and Primate Models

Advanced Functional Materials, EarlyView.
Structure–activity relationship (SAR) optimization of bio‐reducible ionizable lipids enables the development of highly effective lipid nanoparticle (LNP) mRNA vaccines. Lead LNPs show superior tolerability and antibody responses in rodents and primates, outperforming approved COVID‐19 vaccine lipids.
Ruben De Coen, Sabah Kasmi, Shrinivas Dumbre, Lies Baekens, Elise Seynaeve, Louise Van den Hauwe, Niccolò Cantini, Aello Garantoudi, Filipe Branco Madeira, Alain Marrot, Emma Tuypens, Sofie Seghers, Anna Kuchmiy, Elisabeth Brabants, Bart Vanderborght, Ine Maes, Sarah Vandenberghe, Jessica Filtjens, Alícia Gordún Peiró, Daliya Kancheva, Ayla Debraekeleer, Florence Lambolez, Emily De Lombaerde, Yong Chen, Rafael Miyazawa Martins, Pauline Formaglio, Damya Laoui, Sofie Deschoemaeker, Bruno G. De Geest, Rogerio Amino, Stefaan De Koker   +30 more
wiley   +1 more source

Constraining models of dominance for nonsynonymous mutations in the human genome. [PDF]

PLoS Genet
Kyriazis CC, Lohmueller KE.
europepmc   +1 more source

A Smart Bio‐Battery Facilitates Diabetic Bone Defect Repair Via Inducing Macrophage Reprogramming and Synergistically Modulating Bone Remodeling Coupling

Advanced Functional Materials, EarlyView.
This research presents a novel implantable bio‐battery, GF‐OsG, tailored for diabetic bone repair. GF‐OsG generates microcurrents in high‐glucose conditions to enhance vascularization, shift macrophages to the M2 phenotype, and regulate immune responses.
Nanning Lv, Haifu Sun, Wenxiang Tang, Yonggang Li, Zhonglai Qian, Lihui Hong, Chong Chen, Hongye Li, Jiaxiang Bai, Yusen Qiao, Mingming Liu   +10 more
wiley   +1 more source

RNA‐Micelles as Self‐Assembling Structures for Efficient Co‐Delivery of Synergistic siRNA and Nucleoside Analogues to Treat CRC Lung Metastasis

Advanced Functional Materials, EarlyView.
Two kinds of self‐assembled RNA micelles were used to co‐deliver synergistic siRNA and nucleoside analogues for the treatment of colorectal cancer lung metastases. Near‐complete elimination of lung cancer metastases was confirmed in an orthotopic lung metastasis model constructed using human colorectal cancer lung metastases patient surgical samples to
Kai Jin, Piotr Rychahou, Daniel W. Binzel, B. Mark Evers, Peixuan Guo   +4 more
wiley   +1 more source

SUMMER: an integrated nanopore sequencing pipeline for variants detection and clinical annotation on the human genome. [PDF]

Funct Integr Genomics
Li R, Chu H, Gao K, Luo H, Jiang Y.
europepmc   +1 more source

Preventive Human Genome Editing and Enhancement: Candidate Criteria for Governance. [PDF]

Hastings Cent Rep
Juengst E, Flatt MA, Conley JM, Davis A, Henderson G, MacKay D, Major R, Walker RL, Cadigan RJ.   +8 more
europepmc   +1 more source

Replicative DNA polymerase epsilon and delta holoenzymes show wide-ranging inhibition at G-quadruplexes in the human genome. [PDF]

Nucleic Acids Res
Hile SE, Weissensteiner MH, Pytko KG, Dahl J, Kejnovsky E, Kejnovská I, Hedglin M, Georgakopoulos-Soares I, Makova KD, Eckert KA.   +9 more
europepmc   +1 more source

Functional characteristics and computational model of abundant hyperactive loci in the human genome. [PDF]

Elife
Hudaiberdiev S, Ovcharenko I.
europepmc   +1 more source