Results 71 to 80 of about 2,026,261 (344)

Draft Genome Sequence of the Serratia rubidaea CIP 103234T Reference Strain, a Human-Opportunistic Pathogen. [PDF]

, 2015
We provide here the first genome sequence of a Serratia rubidaea isolate, a human-opportunistic pathogen.
Bonnin, RA, Dortet, L, Girlich, D, Imanci, D, Naas, T   +4 more
core   +1 more source

Dynamic disequilibrium-based pathogenicity model in mutated pyrin’s B30.2 domain—Casp1/p20 complex

Journal of Genetic Engineering and Biotechnology, 2022
Background The B30.2 variants lead to most relevant severity forms of familial Mediterranean fever (FMF) manifestations. The B30.2 domain plays a key role in protein-protein interaction (PPI) of pyrin with other apoptosis proteins and in regulation the ...
Alaaeldin G. Fayez, Ghada Nour Eldeen, Waheba A. Zarouk, Khaled Hamed, Abeer Ramadan, Bardees M. Foda, Maha M. Kobesiy, Mai E. Zekrie, Randa S. Lotfy, Mona F. Sokkar, Hala T. El-Bassyouni   +10 more
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Vacuolar transport and function of Saccharomyces cerevisiae sterol ester hydrolase Tgl1

FEBS Letters, EarlyView.
Tgl1, one of yeast sterol ester hydrolases, had been found on the lipid droplets where sterol esters are mainly stored. This study revealed that Tgl1 is transported into the vacuole depending on the ESCRT‐I–III complex, and that it exhibits intra‐vacuolar sterol ester hydrolase activity.
Takumi Nakatsuji, Kosuke Shiraishi, Chuqian Wang, Hiroya Yurimoto, Yasuyoshi Sakai, Masahide Oku   +5 more
wiley   +1 more source

Unconventional machine learning of genome-wide human cancer data

, 2020
Recent advances in high-throughput genomic technologies coupled with exponential increases in computer processing and memory have allowed us to interrogate the complex aberrant molecular underpinnings of human disease from a genome-wide perspective ...
Bajaj, Sweta R., Chittenden, Thomas W., Cilfone, Nicholas, Gamel, Omar E., Gujja, Sharvari, Gulcher, Jeffrey R., Li, Richard Y., Lidar, Daniel A.   +7 more
core   +1 more source

Pathways and Mechanisms that Prevent Genome Instability in Saccharomyces cerevisiae. [PDF]

, 2017
Genome rearrangements result in mutations that underlie many human diseases, and ongoing genome instability likely contributes to the development of many cancers.
Kolodner, Richard D, Putnam, Christopher D   +1 more
core   +1 more source

Human Adipose-Derived Mesenchymal Stromal Cells Injected Systemically into GRMD Dogs without Immunosuppression are Able to Reach the Host Muscle and Express Human Dystrophin

Cell Transplantation, 2012
Duchenne muscular dystrophy (DMD), a lethal X-linked disorder, is the most common and severe form of muscular dystrophies, affecting 1 in 3,500 male births. Mutations in the DMD gene lead to the absence of muscle dystrophin and a progressive degeneration
N. M. Vieira, M. Valadares, E. Zucconi, M. Secco, C. R. Bueno Junior, V. Brandalise, A. Assoni, J. Gomes, V. Landini, T. Andrade, H. V. A. Caetano, M. Vainzof, M. Zatz   +12 more
doaj   +1 more source

The role of fibroblast growth factors in cell and cancer metabolism

FEBS Letters, EarlyView.
Fibroblast growth factor (FGF) signaling regulates crucial signaling cascades that promote cell proliferation, survival, and metabolism. Therefore, FGFs and their receptors are often dysregulated in human diseases, including cancer, to sustain proliferation and rewire metabolism.
Jessica Price, Chiara Francavilla
wiley   +1 more source

A high-resolution map of human evolutionary constraint using 29 mammals. [PDF]

, 2011
The comparison of related genomes has emerged as a powerful lens for genome interpretation. Here we report the sequencing and comparative analysis of 29 eutherian genomes.
Alföldi, Jessica, Baldwin, Jen, Baylor College of Medicine Human Genome Sequencing Center Sequencing Team, Beal, Kathryn, Birney, Ewan, Bloom, Toby, Broad Institute Sequencing Platform and Whole Genome Assembly Team, Chang, Jean, Chin, Chee Whye, Clamp, Michele, Clawson, Hiram, Cree, Andrew, Cuff, James, Delehaunty, Kim, Di Palma, Federica, Dihn, Huyen H, Dooling, David, Ernst, Jason, Fitzgerald, Stephen, Flicek, Paul, Fowler, Gerald, Fronik, Catrina, Fulton, Bob, Fulton, Lucinda, Garber, Manuel, Genome Institute at Washington University, Gibbs, Richard A, Gnerre, Sante, Goldman, Nick, Graves, Tina, Green, Eric D, Guttman, Mitchell, Haussler, David, Heiman, Dave, Herrero, Javier, Holloway, Alisha K, Hubisz, Melissa J, Jaffe, David B, Jhangiani, Shalili, Jordan, Gregory, Joshi, Vandita, Jungreis, Irwin, Kellis, Manolis, Kent, W James, Kheradpour, Pouya, Kostka, Dennis, Kovar, Christie L, Lander, Eric S, Lara, Marcia, Lee, Sandra, Lewis, Lora R, Lin, Michael F, Lindblad-Toh, Kerstin, Lowe, Craig B, Mardis, Elaine R, Margulies, Elliott H, Martins, Andre L, Massingham, Tim, Mauceli, Evan, Minx, Patrick, Moltke, Ida, Muzny, Donna M, Nazareth, Lynne V, Nicol, Robert, Nusbaum, Chad, Okwuonu, Geoffrey, Parker, Brian J, Pedersen, Jakob S, Pollard, Katherine S, Raney, Brian J, Rasmussen, Matthew D, Robinson, Jim, Santibanez, Jireh, Siepel, Adam, Sodergren, Erica, Stark, Alexander, Vilella, Albert J, Ward, Lucas D, Warren, Wesley C, Washietl, Stefan, Weinstock, George M, Wen, Jiayu, Wilkinson, Jane, Wilson, Richard K, Worley, Kim C, Xie, Xiaohui, Young, Sarah, Zody, Michael C, Zuk, Or   +88 more
core   +1 more source

The IQ‐compete assay for measuring mitochondrial protein import efficiencies in living yeast cells

FEBS Letters, EarlyView.
The efficiency of mitochondrial protein import depends on the properties of the newly synthesized precursor proteins. The Import and de‐Quenching Competition (IQ‐compete) assay is a novel method to monitor the import efficiency of different proteins by fluorescence in living yeast cells.
Yasmin Hoffman, Annika Egeler, Saskia Rödl, Johannes M. Herrmann   +3 more
wiley   +1 more source