Results 111 to 120 of about 644,208 (305)
Agriculture driving male expansion in Neolithic Time [PDF]
arXiv, 2013 The emergence of agriculture is suggested to have driven extensive human population growths. However, genetic evidence from maternal mitochondrial genomes suggests major population expansions began before the emergence of agriculture. Therefore, role of agriculture that played in initial population expansions still remains controversial.
arxiv
Impact of the Human Genome Project on Epidemiologic Research [PDF]
, 1997 Darrell L. Ellsworth +2 more
openalex +1 more source
Molecular Oncology, EarlyView.Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser +11 more
wiley +1 more source
Human Genome Book: Words, Sentences and Paragraphs [PDF]
arXivSince the completion of the human genome sequencing project in 2001, significant progress has been made in areas such as gene regulation editing and protein structure prediction. However, given the vast amount of genomic data, the segments that can be fully annotated and understood remain relatively limited.
arxiv
Understanding Transcriptional Regulation Using De-novo Sequence Motif Discovery, Network Inference and Interactome Data [PDF]
arXiv, 2007 Gene regulation is a complex process involving the role of several genomic elements which work in concert to drive spatio-temporal expression. The experimental characterization of gene regulatory elements is a very complex and resource-intensive process.
arxiv
A “Quality-First” Credo for the Human Genome Project [PDF]
, 1998 Maynard V. Olson, Phil Green
openalex +1 more source
Germline variants in CDKN2A wild‐type melanoma prone families
Molecular Oncology, EarlyView.Among melanoma‐prone families, wild‐type for CDKN2A and CDK4, some have pathogenic variants in genes not usually linked to melanoma. Furthermore, rare XP‐related variants and variants in MC1R are enriched in such families. Germline pathogenic variants in CDKN2A are well established as an underlying cause of familial malignant melanoma. While pathogenic
Gjertrud T. Iversen +5 more
wiley +1 more source
Analysis of Chromosome 20 - A Study [PDF]
The 6th International Conference on Computational Systems-Biology
and Bioinformatics 2015, 2016 Since the arrival of next-generation sequencing technologies the amount of genetic sequencing data has increased dramatically. This has has fueled an increase in human genetics research. At the same time, with the recent advent of technologies in processing large data sets, lot of these technologies are proving valuable and efficient in analyzing these
arxiv
Molecular Oncology, EarlyView.Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu +11 more
wiley +1 more source