Results 41 to 50 of about 948,823 (313)
Anaplastic thyroid cancer: genome-based search for new targeted therapy options
Endocrine Connections, 2022 Objective: Anaplastic thyroid cancer (ATC) is one of the most lethal human cancers with meager treatment options. We aimed to identify the targeted drugs already approved by the Food and Drug Administration (FDA) for solid cancer in general, which could ...
Daniel Alexander Hescheler +6 more
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Targeted Therapy of Papillary Thyroid Cancer: A Comprehensive Genomic Analysis
Frontiers in Endocrinology, 2021 BackgroundA limited number of targeted therapy options exist for papillary thyroid cancer (PTC) to date. Based on genetic alterations reported by the “The Cancer Genome Atlas (TCGA)”, we explored whether PTC shows alterations that may be targetable by ...
Daniel A. Hescheler +8 more
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Race: How the Post-Genomic Era Has Unmasked a Misconception Promoted by Healthcare
Medicina, 2023 The term “race” has been employed to categorize human beings into distinct groups based on some perceived biological distinctions. This concept was debunked with the completion of the Human Genome Project and its revolutionary findings that all humans ...
Donna Schaare +2 more
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Frontiers in Immunology, 2023 Primary biliary cholangitis (PBC) is a rare autoimmune disease with a clear predisposition for human leukocyte antigen (HLA)-DR/DQ-associated loss of immune tolerance for the E2 component of the pyruvate dehydrogenase complex.
Seik-Soon Khor +13 more
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A map of human genome variation from population-scale sequencing
Nature, 2010 The 1000 Genomes Project aims to provide a deep characterization of human genome sequence variation as a foundation for investigating the relationship between genotype and phenotype.
G. Abecasis +7 more
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The human genome sequencing race ended 20 years ago [PDF]
The Ukrainian Biochemical Journal, 2020 The Human Genome Project, one of the most grandiose in contemporary science, was officially launched in 1990. The project aimed at determining the human DNA primary structure and gene localization and functions as well as ensuring free access of ...
M. V. Grigorieva, S. V. Komisarenko
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Genome Biology, 2020 In vivo research is critical to the functional dissection of multi-organ systems and whole organism physiology, and the laboratory mouse remains a quintessential animal model for studying mammalian, especially human, pathobiology.
K. C. K. Lloyd +46 more
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Bacteria-human somatic cell lateral gene transfer is enriched in cancer samples. [PDF]
PLoS Computational Biology, 2013 There are 10× more bacterial cells in our bodies from the microbiome than human cells. Viral DNA is known to integrate in the human genome, but the integration of bacterial DNA has not been described. Using publicly available sequence data from the human
David R Riley +6 more
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Unraveling Mycobacterium tuberculosis acid resistance and pH homeostasis mechanisms
FEBS Letters, EarlyView.Mycobacterium tuberculosis exhibits a remarkable resilience to acid stress. In this Review, we discuss some of the molecular mechanisms and metabolic pathways used by the tubercle bacilli to adapt and resist host‐mediated acid stress. Mycobacterium tuberculosis (Mtb) is a successful pathogen that has developed a variety of strategies to survive and ...
Janïs Laudouze +3 more
wiley +1 more source
Life in our hands? Some ethical perspectives on the human genome and human genome diversity projects
Verbum et Ecclesia, 2014 The article dealt with implications of the human genome and the human genome diversity project. It examined some theological implications, such as: humans as the image of God, God as the creator of life, the changed role of miracles and healings in ...
Cornelius W. du Toit
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