Results 81 to 90 of about 908,738 (290)
Entrepreneurial Experiments in Science Policy: Analizing the Human Genome Project [PDF]
We re-conceptualize the role of science policy makers, envisioning and illustrating their move from being simple investors in scientific projects to entrepreneurs who create the conditions for entrepreneurial experiments and initiate them.
Fiona E. Murray, Kenneth G. Huang
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Molecular Oncology, EarlyView.A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He +8 more
wiley +1 more source
An Integrated Encyclopedia of DNA Elements in the Human Genome [PDF]
, 2012 The human genome encodes the blueprint of life, but the function of the vast majority of its nearly three billion bases is unknown. The Encyclopedia of DNA Elements (ENCODE) project has systematically mapped regions of transcription, transcription factor
Khatun, Jainab
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Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Fluorescent Based Technologies and Human Genome Project
Journal of Associated Medical Sciences, 2015 -
Wasun Chantratita
doaj
Science vs. Profit in Research. Lessons from the Human Genome Project [PDF]
This paper elaborates on the recent race to sequence the human genome. Starting from the debate on public vs. private research arising from the genome case, the paper shows that in some fundamental research areas, where knowledge externalities play an ...
Alessandra Pomè +2 more
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Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Long antisense non-coding RNAs and the epigenetic regulation of gene expression
Biomolecular Concepts, 2013 Shortly after the completion of the human genome project in 2003, the Encode project was launched. The project was set out to identify the functional elements in the human genome, and unexpectedly it was found that >80% of the genome is transcribed.
Vadaie Nadia, Morris Kevin V.
doaj +1 more source
Open questions: How many genes do we have?
BMC Biology, 2018 Seventeen years after the initial publication of the human genome, we still haven’t found all of our genes. The answer turns out to be more complex than anyone had imagined when the Human Genome Project began.
Steven L. Salzberg
doaj +1 more source
Using genotyping-by-sequencing to understand Musa diversity : [P449] [PDF]
, 2014 This project is part of a larger effort to apply genomics technologies to assess genetic diversity and to advance genetic improvement efforts in Musa (banana and plantain), a major staple food crop in the developing world.
Chan, Agnes P. +6 more
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