Results 71 to 80 of about 1,820,127 (391)

Recombinant human growth hormone in the treatment of Turner syndrome

Therapeutics and Clinical Risk Management, 2008
Bessie E SpiliotisDivision of Pediatric Endocrinology and Diabetes, Department of Pediatrics, University of Patras, School of Medicine, Patras, GreeceAbstract: Turner syndrome (TS) is a common chromosomal disorder in women that is associated with the ...
Bessie E Spiliotis
doaj  

Response to three years of growth hormone therapy in girls with Turner syndrome [PDF]

Annals of Pediatric Endocrinology & Metabolism, 2013
PurposeShort stature is the most common finding in patients with Turner syndrome. Improving the final adult height in these patients is a challenge both for the patients and physicians.
Hong Kyu Park, Hae Sang Lee, Jung Hee Ko, Il Tae Hwang, Jin Soon Hwang   +4 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Far-infrared rays control prostate cancer cells _in vitro_ and _in vivo_ [PDF]

, 2008
We introduce a new effective method to control hormone refractory prostate cancer cells by using an activated rubber/resin form (RB), far-infrared ray emitter, with or without sodium butyrate (SB).
Hiroki Shima, Jun Qiu, Mayumi Shincho, Reigetsu Yoshikawa, Seiichi Hirota, Shingo Yamamoto, Tomoko Hashimoto-Tamaoki, Yoshie Yoshikawa   +7 more
core   +2 more sources

Estrone and estradiol concentrations in human ovaries, testes, and adrenals during the first two years of life [PDF]

, 1987
To determine the origin of estrogens in infant blood, we measured estrone (E1) and estradiol (E2) in the gonads of 50 girls and 64 boys who died suddenly between birth and 2 yr of age as well as in the adrenals of 18 of these infant girls and 16 of the ...
Bidlingmaier, F., Dorr, H. G., Eisenmenger, Wolfgang, Knorr, D., Strom, T. M.   +4 more
core   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Optimization of production of recombinant human growth hormone in Escherichia coli

Journal of Research in Medical Sciences, 2012
Background: Human growth hormone (hGH) is a single-chain polypeptide that participates in a wide range of biological functions such as metabolism of proteins, carbohydrates and lipids as well as in growth, development and immunity.
Marzieh Rezaei, Sayyed H Zarkesh-Esfahani   +1 more
doaj  

Recombinant growth hormone for children with systemic lupus erythematosus and linear growth delay: A report of two cases and literature review

Journal of International Medical Research
Linear growth delay is common in children with systemic lupus erythematosus. There have been scattered reports of using recombinant human growth hormone in these children, but safety remains a major concern.
Fujuan Liu, Xiaoying Yuan, Yanjun Yang, Yanan Han, Lanlan Ge, Jingxiao Guo, Ling Liu, Chunzhen Li, Dongfeng Zhang   +8 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Sleep deprivation and diet affect human GH gene expression in transgenic mice in vivo

Endocrine Connections, 2020
Human (h) growth hormone (GH) production studies are largely li mited to effects on secretion. How pituitary hGH gene (hGH-N/GH1) expression is regulated is important in our understanding of the role hGH plays in physiology and disease.
Jessica S Jarmasz, Yan JinYan Jin, Hana Vakili, Peter A Cattini   +3 more
doaj   +1 more source