Results 71 to 80 of about 13,138,637 (305)
The influence of growth hormone deficiency on bone health and metabolism
, 2023 Growth hormone (GH) is a key peptide hormone in the regulation of bone metabolism, through its systemic and paracrine action mediated directly as well as by insulin-like growth factor-1 (IGF-1).
Jakub Wydra +3 more
core +1 more source
Frontiers in EndocrinologyBackgroundLong-acting growth hormone (LAGH) formulations have emerged as an alternative to daily recombinant human growth hormone (rhGH) in pediatric growth hormone deficiency (GHD).
Lidia Castro-Feijóo +5 more
doaj +1 more source
Neoplasia: An International Journal for Oncology Research, 2000 Antagonists of growth hormone-releasing hormone(GH-RH) inhibit the growth of various cancers by mechanisms that involve the suppression of the insulin-like growth factor (IGF) -I and/or IGF-II.
Hippokratis Kiaris +2 more
doaj +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
HORMONAL REPLACEMENT THERAPY IN FISH - HUMAN GROWTH-HORMONE GENE-FUNCTION IN HYPOPHYSECTOMIZED CARP
, 1993 Transgenic common carp, Cyprinus carpio, produced by the microinjection of fertilized eggs with a linearized chimeric plasmid pMThGH, a human growth hormone (hGH) gene with a mouse metallothionein-I (MT) gene promoter in pBR322, were used to produce F1 ...
Zuoyan Zhu, Zongbin Cui
core
Growth hormone (GH) provocation tests and the response to GH treatment in GH deficiency [PDF]
, 2004 Objective: To identify factors, particularly the growth hormone (GH) provocation test result, affecting growth response to GH treatment in children with GH deficiency (GHD).Subjects: A total of 337 prepubertal GHD patients aged,10 years from the UK ...
Hindmarsh, PC, Dunger, DB, Cole, TJ
core
Management of growth hormone deficiency in adults
, 2007 Growth hormone (GH) deficiency in adults is a recognised clinical entity. There is still, however, an ongoing debate of the clinical need and the importance of replacing GH in adults with severe GH deficiency.
Nilsson, Anna G, +2 more
core +1 more source
Sleep deprivation and diet affect human GH gene expression in transgenic mice in vivo
Endocrine Connections, 2020 Human (h) growth hormone (GH) production studies are largely li mited to effects on secretion. How pituitary hGH gene (hGH-N/GH1) expression is regulated is important in our understanding of the role hGH plays in physiology and disease.
Jessica S Jarmasz +3 more
doaj +1 more source
The Molecular Properties of Human Growth Hormone
Journal of Biological Chemistry, 1972 Abstract The stability of human growth hormone to acid, alkali, and urea has been evaluated by fluorescence, absorption, and circular dichroism spectroscopy. In accord with previous studies on other growth hormones and prolactins, similar molecular transitions were observed although small shifts in parameters were found among the different proteins. It
ALOJ, SALVATORE MARIA, EDELHOCH H.
openaire +3 more sources
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source