Results 61 to 70 of about 406,651 (306)

Comparative pharmacokinetics and pharmacodynamics of a PEGylated recombinant human growth hormone and daily recombinant human growth hormone in growth hormone-deficient children

Drug Design, Development and Therapy, 2015
Ling Hou,1,* Zhi-hang Chen,2,* Dong Liu,3 Yuan-guo Cheng,2 Xiao-ping Luo1 1Department of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 2Department of Pharmacy, Beijing Institute of ...
Hou L, Chen ZH, Liu D, Cheng YG, Luo XP
doaj  

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Human growth hormone produced with recombinant DNA technology [PDF]

BIO Web of Conferences
Hormones affect the metabolism by stimulating the genetic apparatus of the cell, activating enzymes and changing the rate of enzymatic reactions. They increase the formation of informative ribonucleic acid, which determines the structure of the protein ...
Mustafakulov Muhammad, Uralov Abdumannon, Ahmedova Sobira, Saidov Zukhriddin   +3 more
doaj   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

THE EFFECT OF INJECTION OF THE RECOMBINANT HUMAN GROWTH HORMONE INTO INDUCED TEMPOROMANDIBULAR JOINT ARTHRITIS (AN EXPERIMENTAL STUDY) [PDF]

Alexandria Dental Journal, 2018
INTRODUCTION: Recombinant human growth hormone (rHGH) plays a central role for several metabolic functions including remodeling of bone and cartilage differentiation.
Nesma M. Khalil, Riham M. Eldibany, Samraa A. El-Sheikh, Mohammed A. Altam   +3 more
doaj   +1 more source

HORMONAL REPLACEMENT THERAPY IN FISH - HUMAN GROWTH-HORMONE GENE-FUNCTION IN HYPOPHYSECTOMIZED CARP [PDF]

, 1993
Transgenic common carp, Cyprinus carpio, produced by the microinjection of fertilized eggs with a linearized chimeric plasmid pMThGH, a human growth hormone (hGH) gene with a mouse metallothionein-I (MT) gene promoter in pBR322, were used to produce F1 ...
Zuoyan Zhu, Zongbin Cui
core  

Bioinformatics tools and databases for the study of human growth hormone [PDF]

, 2012
Advances in novel molecular biological diagnostic methods are changing the way of diagnosis and study of metabolic disorders like growth hormone deficiency. Faster sequencing and genotyping methods require strong bioinformatics tools to make sense of the
Amit V. Pandey, Pandey, Amit Vikram
core   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Growth hormone attenuates skeletal muscle changes in experimental chronic heart failure [PDF]

, 2010
Objective: This study evaluated the effects of growth hormone (GH) on morphology and myogenic regulatory factors (MRF) gene expression in skeletal muscle of rats with ascending aortic stenosis (AAS) induced chronic heart failure.Design: Male 90-100 g ...
dos Santos, Denis Pioli, Padovani, Carlos Roberto, Okoshi, Katashi [UNESP], Alves de Almeida, Fernanda Losi, Seiva, Fabio R. F. [UNESP], Moreira, Vanessa O., Padovani, Carlos Roberto [UNESP], dos Santos, Denis Pioli [UNESP], Cicogna, Antonio Carlos [UNESP], Okoshi, Marina Politi, Alves de Almeida, Fernanda Losi [UNESP], Barros Castro, Ana Valeria, Moreira, Vanessa O. [UNESP], Dal Pai-Silva, Maeli [UNESP], Barros Castro, Ana Valeria [UNESP], Carvalho, Robson Francisco [UNESP], Okoshi, Katashi, Okoshi, Marina Politi [UNESP], Carvalho, Robson Francisco, Cicogna, Antonio Carlos, Dal Pai-Silva, Maeli, Seiva, Fabio R. F.   +21 more
core   +1 more source