Results 81 to 90 of about 406,651 (306)

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Quality of Life of Short-Statured Children Born Small for Gestational Age or Idiopathic Growth Hormone Deficiency Within 1 Year of Growth Hormone Treatment

Frontiers in Pediatrics, 2019
Aside from clinical endpoints like height gain, health-related quality of life has also become an important outcome indicator in the medical field. However, the data on short stature and health-related quality of life is inconsistent.
Julia Quitmann, Janika Bloemeke, Neuza Silva, Neuza Silva, Monika Bullinger, Stefanie Witt, Ilker Akkurt, Desiree Dunstheimer, Christian Vogel, Volker Böttcher, Ursula Kuhnle Krahl, Markus Bettendorf, Eckhard Schönau, Susanne Fricke-Otto, Alexandra Keller, Klaus Mohnike, Helmuth-Günther Dörr   +16 more
doaj   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Growth hormone and aging: a clinical review

Frontiers in Aging
Aging is a complex biological process characterized by functional decline, reduced quality of life, and increased vulnerability to diseases such as type 2 diabetes, cardiovascular conditions, neurodegeneration, and cancer.
Luis E. Fernández-Garza, Luis E. Fernández-Garza, Luis E. Fernández-Garza, Fernando Guillen-Silva, Fernando Guillen-Silva, Marcos A. Sotelo-Ibarra, Marcos A. Sotelo-Ibarra, Andrés Ely Domínguez-Mendoza, Silvia A. Barrera-Barrera, Hugo A. Barrera-Saldaña, Hugo A. Barrera-Saldaña, Hugo A. Barrera-Saldaña, Hugo A. Barrera-Saldaña, Hugo A. Barrera-Saldaña   +13 more
doaj   +1 more source

Sleep deprivation and diet affect human GH gene expression in transgenic mice in vivo

Endocrine Connections, 2020
Human (h) growth hormone (GH) production studies are largely li mited to effects on secretion. How pituitary hGH gene (hGH-N/GH1) expression is regulated is important in our understanding of the role hGH plays in physiology and disease.
Jessica S Jarmasz, Yan JinYan Jin, Hana Vakili, Peter A Cattini   +3 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Pharmocogenetic study on efficacy of recombinant growth hormone treatment in short stature patients with growth hormone deficiency [PDF]

, 2009
[[abstract]]Growth hormone (GH) is the most important one to stimulate human body growth and it is especially significant for children before puberty.
Wei-Cheng Chen
core  

Growth hormone and heart failure: Oxidative stress and energetic metabolism in rats [PDF]

, 2008
Several evidences point for beneficial effects of growth hormone (GH) in heart failure (HF). Taking into account that HF is related with changes in myocardial oxidative stress and in energy generation from metabolic pathways, it is important to clarify ...
Padovani, Carlos Roberto, Novelli, E. L. B., Okoshi, Katashi [UNESP], Nascimento, A. [UNESP], Castro, A. V. B., Nascimento, A., Ebaid, Geovana Xavier, Ebaid, Geovana Xavier [UNESP], Padovani, Carlos Roberto [UNESP], Cicogna, Antonio Carlos [UNESP], Seiva, F. R. F., Rocha, K. K. H. [UNESP], Seiva, F. R. F. [UNESP], Castro, A. V. B. [UNESP], Okoshi, Katashi, Cicogna, Antonio Carlos, Novelli, E. L. B. [UNESP], Rocha, K. K. H.   +17 more
core   +1 more source

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source

Ten years' clinical experience with biosimilar human growth hormone: a review of efficacy data [PDF]

, 2017
Juan Pedro López-Siguero,1 Roland Pfäffle,2 Philippe Chanson,3 Mieczyslaw Szalecki,4,5 Nadja Höbel,6 Markus Zabransky6 1Servicio de Endocrinología Pediátrica, Hospital Materno-Infantil, Hospital Regional Universitario de M&
Zabransky M, Höbel N, Szalecki M, López-Siguero JP, Pfäffle R, Chanson P   +5 more
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