Results 241 to 250 of about 923,221 (312)

Specificities of chemosensory receptors in the human gut microbiota. [PDF]

Proc Natl Acad Sci U S A
Xu W, Jalomo-Khayrova E, Gumerov VM, Ross PA, Köbel TS, Schindler D, Bange G, Zhulin IB, Sourjik V.   +8 more
europepmc   +1 more source

Mechanostimulatory Cues Determine Intestinal Fibroblast Fate and Profibrotic Remodeling in a Physiodynamic Human Gut‐on‐a‐Chip

Advanced Science, EarlyView.
A healthy gut barrier shields underlying fibroblasts from luminal shear forces, illustrating that “good fences make good neighbors.” Barrier damage exposes fibroblasts to shear stress, inducing cell death and the emergence of stress‐adapted, profibrotic fibroblasts. Sustained shear exposure promotes the formation of stiff aggregates of mechanoadapative
Soyoun Min, Nam Than, Yong Cheol Shin, Elif G. Ertugral, Chandrasekhar R. Kothapalli, Olumuyiwa Awoniyi, Hyun Jung Kim   +6 more
wiley   +1 more source

Fibroblast diversity within human gut-associated lymphoid tissues. [PDF]

J Exp Med
Mörbe UM, Junghus FV, Nos G, Jørgensen PB, Ensmenger MJ, Väänänen VA, Wewer MD, Madsen GR, Riis LB, Jakobsen HL, Olsen LR, Brunak S, Nielsen OH, Agace WW.   +13 more
europepmc   +1 more source

Targeting Peptostreptococcus anaerobius with an Iron‐Based Nanozyme Reverses Ferroptosis Resistance and Enhances Antitumor Immunity in Colorectal Cancer

Advanced Science, EarlyView.
An iron‐based nanozyme selectively eliminates intratumoral P. anaerobius while catalytically generating ROS to induce ferroptosis, synergistically suppressing colorectal cancer growth and activating anti‐tumor immunity through immunogenic cell death. ABSTRACT The intratumoral microbiota is a critical determinant of therapeutic outcomes in colorectal ...
Yinghao Cao, Jun Wang, Hanwenchen Wang, Xiang Sun, Fang Fang, Shiying Li, Jianping Liu, Changrong Shi, Pengyuan Qi, Jianhua Zou, Xiaoyuan Chen, Kailin Cai   +11 more
wiley   +1 more source

Exploring differences in the human gut microbiome between Han Chinese and non-Chinese populations. [PDF]

Genome Biol
Wang J, Zhang Z, Chen Y, Zhou X, Xiang J, Yang C, Rodionov DA, Osterman AL, Qiu Q, Deng Y, Liu Y, Wang C, Shang X, Huang L, Sun C, Guo J, Yang Z, Zhai L, Bian Z, Lyu A, Han L, Jia W, Fang X, Zhang L.   +23 more
europepmc   +1 more source

A Tac1‐Expressing Brainstem Pathway Underlies the Pathogenesis of Trigeminal Neuralgia

Advanced Science, EarlyView.
A critical TG‐Sp5CTac1‐PBNTac1 pathway drives trigeminal neuropathic pain (TNP). Tac1‐expressing parabrachial nucleus (PBNTac1) neurons exhibit heightened responses to innocuous stimuli in TNP, and chemogenetic inhibition of these neurons effectively prevents TNP development.
Liting Sun, Jia‐Jia Wang, Xiang‐Yu Li, Xin‐Yi Lin, Juan Li, Qiu‐Tong Yu, Zi‐Han Wang, Xue‐Ping Gao, Lei Jin, Wei‐Ke Li, Tian‐Lin Cheng, Juan Deng   +11 more
wiley   +1 more source

Commensal human gut microbes produce species specific neuroactive compounds. [PDF]

iScience
Tingler AM, Packirisamy C, Gutierrez A, Horvath AE, Grozis M, Haidacher SJ, Hoch KM, Haag AM, Oezguen N, Engevik KA, Engevik AC, Horvath TD, Engevik MA.   +12 more
europepmc   +1 more source

VE‐Cadherin–Actin Regulation Promotes Mechanotransduction and Monolayer Maturation Involving a Tension‐Sensitive Intermediate State

Advanced Science, EarlyView.
This study investigates how endothelial monolayers balance cohesion and plasticity during mechanical stimulation. In HUVECs, shear stress induces a tension‐sensitive intermediate state in which junctional VE‐cadherin and actomyosin relaxation levels coordinate actin/integrin remodeling. This rapid, reversible state strengthens cell junctions, preserves
Jonas Franz, Maria Odenthal‐Schnittler, Jan Philip Kipcke, Jochen Seebach, Zahra Labbaf, Franziska Merten, Vesna Bojovic, Muna Taha, Johannes A. Eble, Erez Raz, Milos Galic, Hans Schnittler   +11 more
wiley   +1 more source

Investigation of bile salt hydrolase activity in human gut bacteria reveals production of conjugated secondary bile acids. [PDF]

Nat Commun
Lucas LN, Jillella M, Cattaneo LE, Gangwar B, Zhang Q, Clay AP, Kerby RL, Stevenson DM, Blackwell HE, Rey FE, Amador-Noguez D.   +10 more
europepmc   +1 more source