Results 251 to 260 of about 923,221 (312)

Targeting the PDK1/c‐Myc/SOX10 Signaling in Oligodendrocytes Alleviates Neuropathic Pain

Advanced Science, EarlyView.
This work reveals that oligodendrocyte homeostasis, mediated by PDK1, is a critical determinant of neuropathic pain (NPP) pathogenesis. Disruption of PDK1 in oligodendrocytes impairs SOX10‐dependent myelination programs through c‐Myc accumulation, leading to disrupted myelination and the pathophysiology of NPP.
Pingping Qiao, Lifang Guo, Guochao Yang, Chaoli Huang, He Wang, Jian‐Jun Yang, Guiquan Chen, Yimin Hu   +7 more
wiley   +1 more source

Metatranscriptomic-driven insights into mucosal glycan degradation by the human gut microbiota. [PDF]

FEMS Microbiol Ecol
Bauchinger F, Berry D.
europepmc   +1 more source

Oral Streptococcus salivarius Couples Neutrophil IRGM1 Signaling to NET Formation and Colorectal Cancer Metastasis

Advanced Science, EarlyView.
The oral bacterium Streptococcus salivarius promotes colorectal cancer metastasis by inducing neutrophil extracellular trap (NET) formation. Mechanistically, IRGM1–IQGAP1 interaction activates Wnt5a–PI3K/AKT signaling in neutrophils, driving NET‐mediated tumor progression.
Fengyi Liu, Yuan Wang, Hengxuan Cai, Qianwen Yue, Xueli Liu, Xuanwen Bao, Zeng Wang, Xuehan Li, Lai Wei, Zhihua Zhang, Fan Xing, Yi Xu, Xianjun Li, Wei Xu   +13 more
wiley   +1 more source

The Intestinal Cues Promoting Serotonin Release From the Human Gut. [PDF]

Cell Mol Gastroenterol Hepatol
Di Rienzi SC.
europepmc   +1 more source

PET Imaging of Cardiac Inflammation in Viral Myocarditis Using a DPP4‐Targeted Probe

Advanced Science, EarlyView.
This study describes a DPP4‐targeted PET probe for imaging myocardial inflammation by selectively targeting activated immune cells. Derived from the clinically approved small‐molecule inhibitor linagliptin, the probe demonstrates favorable biodistribution with specific cardiac uptake in myocarditis.
Wanhao Gao, Wenzhu Hu, Du Tang, Xinxin Liu, Kun Yu, Lixia Feng, Minyu Liao, Wang Lin, Wenqiang Zhu, Sanjay Rajagopalan, Xiaoli Lan, Jixin Zhong, Dao Wen Wang, Dawei Jiang, Xiaoquan Rao   +14 more
wiley   +1 more source

Unusual molecular architecture of a human gut microbiota β-mannanase reveals a new CBM family

Łoś N, Lelėnaitė I, Willats WGT, Terrapon N, Morales-García AL, Yau HCL, Lowe EC, Bolam DN.   +7 more
europepmc   +1 more source

A signature-protein-based approach for accurate and efficient profiling of the human gut virome. [PDF]

Cell Rep Methods
Yang F, Xiong L, Li M, Feng X, Ren H, Shi Z, Zhong H, Li J.   +7 more
europepmc   +1 more source

Alternating High‐Fat and Polysaccharide Diets Modulates Gut Phage‐Bacterial Interplay

Advanced Science, EarlyView.
This study reveals how alternating high‐fat and polysaccharide diets reshape the human gut virome and enhance phage‐bacteria interactions. Using large‐scale metagenomic meta‐analysis and a time‐resolved mouse model, the authors show that diets strongly modulate phage abundance, lifestyle, and gene exchange, offering new insights into nutrition‐guided ...
Fengxiang Zhao, Ruiqi Zhang, Rujun Wei, Huimin Fan, Yongfei Hu, Wenyu Shi, Jinfeng Wang   +6 more
wiley   +1 more source

Convergent genomic responses of human gut bacteria to variations in industrialization

Rühlemann M, Szánthó LL, Waschina S, Moitinho-Silva L, Mews LK, Camarena JF, Jebens H, Costa J, Juimo V, Fezeu A, Agyei A, Afihene MY, Asibey SO, Awuku YA, Duah A, Nartey YA, Ibrahim F, Lim YAL, Pin TM, Onyekwere C, Rusine J, Mwikarago IE, Baines J, Franke A, Szöllősi GJ, Xavier R, Alm EJ, Groussin M, Poyet M.   +28 more
europepmc   +1 more source

Linking the edible plant microbiome and human gut microbiome. [PDF]

Gut Microbes
Berg G, Toledo GV, Schierstaedt J, Hyöty H, Adi Wicaksono W.   +4 more
europepmc   +1 more source