Results 81 to 90 of about 276,156 (305)

A Bifunctional T3SS‐Effector Simultaneously Cleaves Host MAP Kinase and Inhibits PPM1A Phosphatase

Advanced Science, EarlyView.
Pathogenic bacteria exploit the metalloprotease effector NleD to subvert host defenses. Structural, biochemical, and infection analyses reveal a bifunctional mechanism by which NleD binds and inhibits the host phosphatase PPM1A while preserving its proteolytic activity against MAPKs.
Yaakov Socol, Lihi Gur‐Arie, Netanel Tzarum, Tamara Wellins, Naama Katsowich, Miriam Ravins, Michal Bejerano‐Sagie, Klil Cohen, Oded Livnah, Joshua N. Adkins, Ernesto Nakayasu, Alexei Savchenko, Yeu Khai Choong, Nikhil Kumar Tulsian, Saturo Machida, Sigal Ben‐Yehuda, Yael Litvak, J. Sivaraman, Ilan Rosenshine   +18 more
wiley   +1 more source

Effects of 60 days of 6° head-down bed rest on the composition and function of the human gut microbiota

iScience, 2023
Summary: Spaceflight is rigorous and dangerous environment which can negatively affect astronauts’ health and the entire mission. The 60 days of 6° head-down bed rest (HDBR) experiment provided us with an opportunity to trace the change of gut microbiota
Yixuan Li, Zizhong Liu, Gui Luo, Haiyun Lan, Pu Chen, Ruikai Du, Gongchao Jing, Lu Liu, Xiaohan Cui, Yongzhi Li, Yanping Han, Jian Xu, Hongwei Zhu, Shukuan Ling, Yingxian Li   +14 more
doaj   +1 more source

The influence of habitual dietary intake on the responsiveness of the gut microbiota to a dietary intervention : a thesis presented in partial fulfilment of the requirements for the degree of Doctor of Philosophy in Nutritional Science at Massey University, Manawatu, New Zealand [PDF]

, 2017
Preliminary evidence suggests that inter-individual variability in gut microbiota response to a dietary intervention is influenced by baseline gut microbiota composition.
Healey, Genelle Rose
core  

Taxonomic Features and Comparison of the Gut Microbiome from Two Edible Fungus-Farming Termites (Macrotermes falciger, M. natalensis) Harvested in the Vhembe District of Limpopo, South Africa [PDF]

, 2019
Background Termites are an important food resource for many human populations around the world, and are a good supply of nutrients. The fungus-farming ‘higher’ termite members of Macrotermitinae are also consumed by modern great apes and are implicated ...
Duncan, Frances D., Hofman, Courney A., Honap, Tanvi P., Lesnik, Julie, Lewis, Cecil M., Netschifhefhe, Shandukani R., Schnorr, Stephanie L.   +6 more
core   +2 more sources

Gut Mycobiota‐Associated Tryptophan Catabolites Protect Against Metabolic Dysfunction‐Associated Steatotic Liver Disease

Advanced Science, EarlyView.
ABSTRACT Accumulating evidence suggests that the intestinal microbiota participates in the progression of metabolic dysfunction‐associated steatotic liver disease (MASLD) through microbiota‐host interaction. However, the beneficial role of commensal mycobiota in MASLD progression remains poorly understood.
Shuping Qiao, Shuangya Fan, Juan Xu, Zhen Xu, Chen Peng, Junxing Qu, Ziqian Bing, Shizhen Zhou, Sunan Shen, Guifang Xu, Yue Zhao, Tingting Wang   +11 more
wiley   +1 more source

Linking gut microbiota to aging process: a new target for anti-aging

Food Science and Human Wellness, 2018
The human gut microbiota is a huge ecosystem that provides lots of functions for host development, immune system, and metabolism. Gut microbiota is linked to lots of diseases, including human metabolic diseases such as obesity, type 2 diabetes (T2D ...
Maoyang Lu, Zhao Wang
doaj   +1 more source

Microbial Eukaryotes in the Human Microbiome: Ecology, Evolution, and Future Directions [PDF]

, 2011
High throughput sequencing technology has opened a window into the vast communities of bacteria that live on and in humans, demonstrating tremendous variability, and that they play a large role in health and disease. The eukaryotic component of the human
Laura Wegener Parfrey, William A. Walters, Rob Knight   +2 more
core   +1 more source

Time‐Controlled Refrigerated Stem Cell Therapy Mitigates Scleroderma Fibrosis via Modulation of Mitochondrial Autophagy and Gut Metabolism

Advanced Science, EarlyView.
This study established an RT‐MSCs‐based therapeutic approach for scleroderma in mice. RT‐MSCs attenuated fibrosis by regulating mitochondrial autophagy and restored gut microbiota homeostasis. Metabolomic analyses confirmed recovery of key metabolites, and RT‐MSCs demonstrated favorable lesion targeting and safety profiles.
Xue Xia, Chenfei Kong, Xiaoming Zhao, Naixu Shi, Jinlan Jiang, Ping Li   +5 more
wiley   +1 more source

Berries: Health Effects via Modulation of the Gut Microbiota

Food Frontiers
Berries are widely regarded as beneficial foods, rich in polyphenols, flavonoids, and other bioactive compounds that could positively influence human health.
Manjin Xu, Yunfeng Xu, Lizhi Wu, Huixia Niu, Bei Gao, Kai Sun, Xueqing Li, Mingluan Xing, Zhe Mo, Zhijian Chen, Pengcheng Tu, Xiaoming Lou   +11 more
doaj   +1 more source

Unraveling the role of the gut microbiome in pregnancy disorders: insights and implications

Frontiers in Cellular and Infection Microbiology
The gut microbiota is the collective term for the microorganisms that reside in the human gut. In recent years, advances in sequencing technology and bioinformatics gradually revealed the role of gut microbiota in human health.
Yupei Xie, Yupei Xie, Yupei Xie, Qian Chen, Qian Chen, Qian Chen, Dan Shan, Dan Shan, Dan Shan, Xiongfei Pan, Xiongfei Pan, Yayi Hu, Yayi Hu, Yayi Hu   +13 more
doaj   +1 more source