Results 91 to 100 of about 276,156 (305)

Gut Microbiota-Derived Metabolites in the Development of Diseases

Canadian Journal of Infectious Diseases and Medical Microbiology, 2021
Gut microbiota is increasingly recognized as a metabolic organ essential for human health. Compelling evidences show a variety set of links between diets and gut microbial homeostasis.
Guangyu Shen, Jing Wu, Bang-Ce Ye, Nan Qi   +3 more
doaj   +1 more source

Rapid Remodeling of the Human Gut Microbiome in Response to Short‐Term Animal Product Restriction and Associations with Host Molecular Phenotypes

Advanced Science, EarlyView.
A real‐world model of structured animal product restriction practiced for religious reasons reveals the dynamic adaptability of the human gut microbiome to dietary change and uncovers reductions in diversity and rare taxa loss. Integrated microbiome, metabolomic, and proteomic analyses uncover coordinated taxonomic and molecular shifts and identify ...
Christina Emmanouil, Maria Anezaki, Alexandros Simistiras, Stavros Glentis, Nikolaos Scarmeas, Pantelis Hatzis, Konstantinos Rouskas, Antigone S. Dimas   +7 more
wiley   +1 more source

A comprehensive analysis of human gut microbial biosynthesis gene clusters unveiling the dominant role of Paenibacillus

mSystems
The secondary metabolites produced by the gut microbiota serve as crucial signaling molecules and substrates for gastrointestinal metabolic reactions, thereby playing a pivotal role in human physiological and pathological processes.
Han Gao, Daohua Zhuang, Hong Zhou, Qian Su, Xintong Hu, Yuan Wang, Wandong Bao, Lei Zhu   +7 more
doaj   +1 more source

Host lifestyle affects human microbiota on daily timescales [PDF]

, 2013
Background: Disturbance to human microbiota may underlie several pathologies. Yet, we lack a comprehensive understanding of how lifestyle affects the dynamics of human-associated microbial communities.
Alm, Eric J, Baptista, Maria I. C., Blackburn, Matthew C., David, Lawrence A., Erdman, Susan E, Friedman, Jonathan, Materna, Arne C., Perrotta, Allison, Perrotta, Allison   +8 more
core   +3 more sources

Mechanostimulatory Cues Determine Intestinal Fibroblast Fate and Profibrotic Remodeling in a Physiodynamic Human Gut‐on‐a‐Chip

Advanced Science, EarlyView.
A healthy gut barrier shields underlying fibroblasts from luminal shear forces, illustrating that “good fences make good neighbors.” Barrier damage exposes fibroblasts to shear stress, inducing cell death and the emergence of stress‐adapted, profibrotic fibroblasts. Sustained shear exposure promotes the formation of stiff aggregates of mechanoadapative
Soyoun Min, Nam Than, Yong Cheol Shin, Elif G. Ertugral, Chandrasekhar R. Kothapalli, Olumuyiwa Awoniyi, Hyun Jung Kim   +6 more
wiley   +1 more source

Food Design To Feed the Human Gut Microbiota [PDF]

Journal of Agricultural and Food Chemistry, 2018
The gut microbiome has an enormous impact on the life of the host, and the diet plays a fundamental role in shaping microbiome composition and function. The way food is processed is a key factor determining the amount and type of material reaching the gut bacteria and influencing their growth and the production of microbiota metabolites.
Ercolini, Danilo, Fogliano, Vincenzo
openaire   +3 more sources

Type 2 diabetes mellitus-related environmental factors and the gut microbiota: emerging evidence and challenges [PDF]

Clinics
The gut microbiota is a group of over 38 trillion bacterial cells in the human microbiota that plays an important role in the regulation of human metabolism through its symbiotic relationship with the host.
Yanfen Liu, Xueyong Lou
doaj   +2 more sources

Dietary Uncoupling of Gut Microbiota and Energy Harvesting from Obesity and Glucose Tolerance in Mice [PDF]

, 2017
The authors gratefully acknowledge Doctoral Training Partnership funding from the BBSRC (M.J.D.) and funding from the Scottish Government (P.J.M., A.W.R., and A.W.W.).
Dalby, Matthew J., Morgan, Peter J., Ross, Alexander W., Walker, Alan W.   +3 more
core   +2 more sources

Targeting Peptostreptococcus anaerobius with an Iron‐Based Nanozyme Reverses Ferroptosis Resistance and Enhances Antitumor Immunity in Colorectal Cancer

Advanced Science, EarlyView.
An iron‐based nanozyme selectively eliminates intratumoral P. anaerobius while catalytically generating ROS to induce ferroptosis, synergistically suppressing colorectal cancer growth and activating anti‐tumor immunity through immunogenic cell death. ABSTRACT The intratumoral microbiota is a critical determinant of therapeutic outcomes in colorectal ...
Yinghao Cao, Jun Wang, Hanwenchen Wang, Xiang Sun, Fang Fang, Shiying Li, Jianping Liu, Changrong Shi, Pengyuan Qi, Jianhua Zou, Xiaoyuan Chen, Kailin Cai   +11 more
wiley   +1 more source

Functional modulation of the human gut microbiome by bacteria vehicled by cheese

Applied and Environmental Microbiology
Since cheese is one of the most commonly and globally consumed fermented foods, scientific investigations in recent decades have focused on determining the impact of this dairy product on human health and well-being.
Christian Milani, Giulia Longhi, Giulia Alessandri, Federico Fontana, Martina Viglioli, Chiara Tarracchini, Leonardo Mancabelli, Gabriele Andrea Lugli, Silvia Petraro, Chiara Argentini, Rosaria Anzalone, Alice Viappiani, Elisa Carli, Federica Vacondio, Douwe van Sinderen, Francesca Turroni, Marco Mor, Marco Ventura   +17 more
doaj   +1 more source