Results 61 to 70 of about 226,444 (263)

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant   +11 more
wiley   +1 more source

Importance of methodological details in the measurement of cortisol in human hair

open access: yesEndocrine Regulations, 2018
Objective. The measurement of cortisol in hair became a popular and frequently used methodology in human stress research. This methodological approach, depending on the length of hair analyzed, allows to reflect cortisol secretion over prolong time ...
Balagova Lucia, Jezova Daniela
doaj   +1 more source

Insights from mercury stable isotopes into factors affecting the internal body burden of methylmercury in frequent fish consumers

open access: yesElementa: Science of the Anthropocene, 2016
Methylmercury (MeHg) exposure can cause adverse health effects in children and adults and is predominantly from seafood consumption in the United States (U.S.). Here we examine evidence for differences in MeHg uptake and metabolism in U.S.
Miling Li   +6 more
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

open access: yesFEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz   +6 more
wiley   +1 more source

Fabrication and characterization of chitosan coated human hair reinforced phytagel modified soy protein-based green composite

open access: yesJournal of the Mechanical Behavior of Materials, 2018
In the present investigation, human hair reinforced soy protein isolate (SPI)-based green composites modified with 40 wt.% phytagel and 12.5 wt.% glycerol were developed.
Deepmala Km   +3 more
doaj   +1 more source

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

open access: yesFEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar   +4 more
wiley   +1 more source

The use of human hair as biodosimeter

open access: yesApplied Radiation and Isotopes, 2014
The potential use of human hair samples as biologic dosimeter was investigated by electron spin resonance (ESR) spectroscopy. The hair samples were obtained from female volunteers and classified according to the color, age and whether they are natural or dyed. Natural black, brown, red, blonde and dyed black hair samples were irradiated at low doses (5-
Tepe Çam, Semra   +2 more
openaire   +4 more sources

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

open access: yesFEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro   +1 more
wiley   +1 more source

KONTAMINASI MERKURI PADA SAMPEL LINGKUNGAN DAN FAKTOR RISIKO PADA MASYARAKAT DARI KEGIATAN PENAMBANGAN EMAS SKALA KECIL KRUENG SABEE PROVINSI ACEH (Mercury Contamination in the Environmental Samples and Risk Factors in Inhabitants of the Small Scale Gold)

open access: yesJurnal Manusia dan Lingkungan, 2016
ABSTRAK Kegiatan penambangan emas skala kecil dengan teknik amalgamasi dapat memberikan peluang introduksi merkuri (Hg) ke lingkungan dan manusia. Penelitian kontaminasi Hg pada air minum, ikan, rambut kepala manusia, dan faktor risiko pada manusia ...
Sofia Sofia, Adi Heru Husodo
doaj   +1 more source

Delivery of DNA‐encoded vaccines and proteins in mice using cutaneous suction‐mediated transfection

open access: yesFEBS Open Bio, EarlyView.
Cutaneous suction‐mediated transfection in mice for delivery of DNA‐encoded vaccines and proteins. A critical limitation of DNA vaccines and other therapeutics is transfection in vivo to produce the encoded antigens or therapeutic proteins. Cutaneous suction‐based methods have demonstrated effectiveness in many animal models and have been successfully ...
Emran O. Lallow   +12 more
wiley   +1 more source

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