Results 71 to 80 of about 1,032,126 (309)

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Brief communication: Hair density and body mass in mammals and the evolution of human hairlessness [PDF]

, 2013
Humans are unusual among mammals in appearing hairless. Several hypotheses propose explanations for this phenotype, but few data are available to test these hypotheses. To elucidate the evolutionary history of human “hairlessness,” a comparative approach
Sandel, Aaron A.
core   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Biology of human hair: Know your hair to control it [PDF]

, 2011
Hair can be engineered at different levels—its structure and surface—through modification of its constituent molecules, in particular proteins, but also the hair follicle (HF) can be genetically altered, in particular with the advent of siRNA-based ...
A Dugour, A Franbourg, A Kukita, A Louvi, A Rebora, A Roddick-Lanzilotta, A Rolland, A Slominski, A Teichmann, A Vogt, A Zimek, AA Panteleyev, AE Buhl, AH Weston, AJ Craven, AJ Craven, AJ Reynolds, AM Kligman, AP McMahon, AP Wysocki, B Bhushan, B St-Jacques, BL Hogan, C Blanpain, C Bolduc, C Chiang, C Danciulescu, C Lo Celso, C Nappe, C Pierard-Franchimont, CA Baker, CA Jahoda, CJ Silva, CM Chuong, CP Zhang, CR Borges, CY Logan, DAD Parry, DJ Tobin, E Bernard, E Fuchs, E Oshimura, EK Nishimura, EK Nishimura, F Conrad, F Hueber, G Cotsarelis, G Lindner, G Taylor, G Weinmaster, GC Davies, H Clevers, H Kulessa, H Oshima, H Schell, HB Chase, HS Oh, J Cai, J Huelsken, J Lademann, J Lademann, J Zhang, JA Faucher, JA Swift, JE Plowman, JE Plowman, JH Han, JT Headington, K Foitzik, K Hashimoto, K Kobielak, K Krause, K Narhi, K Schouwey, K Shorter, K Suzuki, KA Holbrook, KK Lin, KM Cadigan, L Karlsson, L Mecklenburg, L Pille, LC Wang, LJ Wolfram, LJ Wolfram, LN Jones, LT Krebs, M Feughelman, M Ito, M Magerl, M Magerl, M Moriyama, M Nakamura, M Ohyama, M Ohyama, M Ohyama, M Philpott, M Saitoh, MA Johnstone, MA Tran, ME Balana, ME Sawaya, MH Kwack, MS Birbeck, MV Plikus, N Beek van, N Otberg, N Sato, N Yamamoto, O Mori, OS Kwon, P Redondo, PW Ingham, R Azziz, R DasGupta, R Dawber, R Kopan, R Paus, R Schmidt-Ullrich, R Schmidt-Ullrich, R Schueller, R Yi, RC Wester, RD Sinclair, RH Wilson, RJ Block, RJ Morris, RK Freinkel, S Chanda, S Claudinot, S Cochran, S Demehri, S Estrach, S Gupta, S Inui, S Iseki, S Itami, S Kondo, S Lyle, S Maretto, S Muller-Rover, S Reddy, S Vauclair, SD O’Connor, SE Millar, SJ Du, SL Mansberger, STA Regismond, T Andl, T Hibino, T Passeron, T Reya, T Sato, T Tumbar, TA Mitsiadis, TA Mitsiadis, TA Smith, TW Fischer, U Blume-Peytavi, U Gat, VA Botchkarev, VA Botchkarev, VA Botchkarev, VA Randall, VA Randall, VA Randall, VA Randall, VM Meidan, Y Ando, Y Asada, Y Barrandon, Y Pan, Y Ramot, YV Zhang   +173 more
core   +1 more source

Trichochromes in red human hair

Acta Dermato-Venereologica, 1978
The presence of trichochromes B and C in red human hair was confirmed with an analytical procedure which does not give rise to the formation of these compounds as artifacts. The trichochrome precursor 5-S-cysteinyldopa previously demonstrated in red guinea-pig hair was not detected in red human hair.
G, Agrup, C, Hansson, H, Rorsman, A M, Rosengren, E, Rosengren   +4 more
openaire   +2 more sources

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

A Style-Based Generator Architecture for Generative Adversarial Networks

, 2019
We propose an alternative generator architecture for generative adversarial networks, borrowing from style transfer literature. The new architecture leads to an automatically learned, unsupervised separation of high-level attributes (e.g., pose and ...
Aila, Timo, Karras, Tero, Laine, Samuli
core   +1 more source

Numerical simulation of the hair formation –modeling of hair cycle [PDF]

, 2018
In the recent years, the fields of study of anti-aging, health and beauty, cosmetics, and hair diseases have attracted significant attention. In particular, human hair is considered to be an important aspect with regard to an attractive appearance.
Kajihara Narumichi, Nagayama Katsuya
core   +2 more sources

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

3D Modelling for Solar Erythemal UV Protection Provided by Human Hair

Applied Sciences, 2019
The head is one of the most sun-exposed anatomical zones and its ultraviolet (UV) exposure is often underestimated. The goal of this research is to quantify the solar erythemal UV protection provided by human hair for different orientations and Solar ...
Arianna Religi, Laurent Moccozet
doaj   +1 more source