Results 71 to 80 of about 9,764,220 (350)

Studies on the Proteome of Human Hair - Identification of Histones and Deamidated Keratins

Scientific Reports, 2018
Human hair is laminar-fibrous tissue and an evolutionarily old keratinization product of follicle trichocytes. Studies on the hair proteome can give new insights into hair function and lead to the development of novel biomarkers for hair in health and ...
S. Adav, Roopa S. Subbaiaih, Swat Kim Kerk, Amelia Yilin Lee, H. Lai, K. Ng, S. Sze, A. Schmidtchen   +7 more
semanticscholar   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

All Sites but Skin Cancer Incidences Analyzed Worldwide by Sex, Age, and Skin Type Over Time (1955-2007), Advancing Age, and UVB Dose Reveals Important Carcinogenic Drivers [PDF]

, 2017
Because we observed increasing incidences over time, advancing age, higher estrogen levels, decreasing UVB (290-315 nm) doses, or lower vitamin D3, and Human Papillomavirus hiding in immune-privileged sites of hair follicles play roles in melanoma, we ...
Godar, Dianne E., Gurov, Rossen, Merrill, Stephen   +2 more
core   +1 more source

Biology of human hair: Know your hair to control it [PDF]

, 2011
Hair can be engineered at different levels—its structure and surface—through modification of its constituent molecules, in particular proteins, but also the hair follicle (HF) can be genetically altered, in particular with the advent of siRNA-based ...
A Dugour, A Franbourg, A Kukita, A Louvi, A Rebora, A Roddick-Lanzilotta, A Rolland, A Slominski, A Teichmann, A Vogt, A Zimek, AA Panteleyev, AE Buhl, AH Weston, AJ Craven, AJ Craven, AJ Reynolds, AM Kligman, AP McMahon, AP Wysocki, B Bhushan, B St-Jacques, BL Hogan, C Blanpain, C Bolduc, C Chiang, C Danciulescu, C Lo Celso, C Nappe, C Pierard-Franchimont, CA Baker, CA Jahoda, CJ Silva, CM Chuong, CP Zhang, CR Borges, CY Logan, DAD Parry, DJ Tobin, E Bernard, E Fuchs, E Oshimura, EK Nishimura, EK Nishimura, F Conrad, F Hueber, G Cotsarelis, G Lindner, G Taylor, G Weinmaster, GC Davies, H Clevers, H Kulessa, H Oshima, H Schell, HB Chase, HS Oh, J Cai, J Huelsken, J Lademann, J Lademann, J Zhang, JA Faucher, JA Swift, JE Plowman, JE Plowman, JH Han, JT Headington, K Foitzik, K Hashimoto, K Kobielak, K Krause, K Narhi, K Schouwey, K Shorter, K Suzuki, KA Holbrook, KK Lin, KM Cadigan, L Karlsson, L Mecklenburg, L Pille, LC Wang, LJ Wolfram, LJ Wolfram, LN Jones, LT Krebs, M Feughelman, M Ito, M Magerl, M Magerl, M Moriyama, M Nakamura, M Ohyama, M Ohyama, M Ohyama, M Philpott, M Saitoh, MA Johnstone, MA Tran, ME Balana, ME Sawaya, MH Kwack, MS Birbeck, MV Plikus, N Beek van, N Otberg, N Sato, N Yamamoto, O Mori, OS Kwon, P Redondo, PW Ingham, R Azziz, R DasGupta, R Dawber, R Kopan, R Paus, R Schmidt-Ullrich, R Schmidt-Ullrich, R Schueller, R Yi, RC Wester, RD Sinclair, RH Wilson, RJ Block, RJ Morris, RK Freinkel, S Chanda, S Claudinot, S Cochran, S Demehri, S Estrach, S Gupta, S Inui, S Iseki, S Itami, S Kondo, S Lyle, S Maretto, S Muller-Rover, S Reddy, S Vauclair, SD O’Connor, SE Millar, SJ Du, SL Mansberger, STA Regismond, T Andl, T Hibino, T Passeron, T Reya, T Sato, T Tumbar, TA Mitsiadis, TA Mitsiadis, TA Smith, TW Fischer, U Blume-Peytavi, U Gat, VA Botchkarev, VA Botchkarev, VA Botchkarev, VA Randall, VA Randall, VA Randall, VA Randall, VM Meidan, Y Ando, Y Asada, Y Barrandon, Y Pan, Y Ramot, YV Zhang   +173 more
core   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

Human hair keratin responds to oxidative stress via reactive sulfur and supersulfides

Advances in Redox Research
Keratin is a central component of human hair proteins, which explicitly possesses many cysteine residues (Cys-SH). For a long time, these Cys-SH residues were believed to contribute to human hair strength by forming intra- and inter-molecular disulfide ...
Takeru Hirai, Mayumi Ikeda-Imafuku, Nanami Tasaka, Victor Tuan Giam Chuang, Ming Xian, Tatsuhiro Ishida, Takaaki Akaike, Yu Ishima   +7 more
doaj   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Nonthermal Argon Plasma Generator and Some Potential Applications

Annals of West University of Timisoara: Physics, 2015
A laboratory - made nonthermal plasma generator is presented. It has a diameter of 0.020 m and length of 0.155 m and contains two electrodes. The first electrode is a 2% Th-W alloy, 0.002 m in diameter bar, centred inside the generator’s body by means of
Bunoiu M., Jugunaru I., Bica I., Balasoiu M.   +3 more
doaj   +1 more source

Twist2-driven chromatin remodeling governs the postnatal maturation of dermal fibroblasts

Cell Reports, 2022
Summary: Dermal fibroblasts lose stem cell potency after birth, which prevents regenerative healing. However, the underlying intracellular mechanisms are largely unknown.
Jin Yong Kim, Minji Park, Jungyoon Ohn, Rho Hyun Seong, Jin Ho Chung, Kyu Han Kim, Seong Jin Jo, Ohsang Kwon   +7 more
doaj   +1 more source

Examination of Fluconazole-Induced Alopecia in an Animal Model and Human Cohort. [PDF]

, 2019
Fluconazole-induced alopecia is a significant problem for patients receiving long-term therapy. We evaluated the hair cycle changes of fluconazole in a rat model and investigated potential molecular mechanisms.
Aaron, Phylicia A, Affolter, Verena K, Dennis, Michael, Everett, Angela D, Fedor, Dawn M, Gelli, Angie, Krois, Charles R, McHardy, Ian, Napoli, Joseph L, Sharon, Victoria R, Singapuri, Anil, Thompson, George R, Varjonen, E Katarina, White, Stephen D, Wiederhold, Nathan P, Yoo, Hong Sik   +15 more
core