Results 41 to 50 of about 27,320,927 (309)

Biomarkers as tools in human health risk assessment

Clinical Chemistry, 1995
Abstract Evaluation of occupational or environmental risk due to exposure to chemicals requires sufficient information on the toxic profiles, mechanisms of action, toxicokinetics, dose-response relation, exposure, and the target dose. Usually exposure is estimated by measuring concentrations of the agent in air, food, water, soil, dust ...
H, Greim, G, Csanády, J G, Filser, P, Kreuzer, L, Schwarz, T, Wolff, S, Werner   +6 more
openaire   +2 more sources

Retrospective Analysis of Donor Lymphocyte Infusions in Pediatric Patients With Mixed Chimerism After Hematopoietic Stem Cell Transplantation

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Allogeneic hematopoietic stem cell transplantation (alloHSCT) is an essential therapy for several malignant and nonmalignant diseases, but relapse and graft loss remain the principal threats to its success. Routine monitoring of chimerism and minimal residual disease (MRD) enables early detection of imminent recurrence and guides ...
Carmen Junk, Sebastian Michaelis, Michaela Döring, Thomas Eichholz, Ursula Holzer, Martin Ebinger, Tim Flaadt, Rupert Handgretinger, Peter Lang, Jan Frederic Weller, Markus Mezger   +10 more
wiley   +1 more source

Scoping a public health impact assessment of aquaculture with particular reference to tilapia in the UK [PDF]

, 2012
Background. The paper explores shaping public health impact assessment tools for tilapia, a novel emergent aquaculture sector in the UK. This Research Council’s UK Rural Economy and Land Use project embraces technical, public health, and marketing ...
Doi, Larry, Watterson, A., Young, J.A., Young, James A., Azim, Ekram, Watterson, Andrew, Boyd, K.A., Murray, F., Young, James, Boyd, Kathleen, Little, David, Doi, L., Little, David C, Boyd, Kathleen A., Little, D., Murray, Francis, Azim, E.   +16 more
core   +1 more source

Research Note: Evaluation of microbial contamination on broiler carcasses – an investigation of body parts and sampling methods

Poultry Science
We investigated whether samples of the neck skin from 24 broiler chickens, which were taken from broiler carcasses after chilling, are representative for the microbiological load (TVC – total viable count 3.99 log10 cfu/g, E.
Bastian Wyink, Alina Kirse, Felix Reich
doaj   +1 more source

Assessment of Human Health Risk of Dioxin in Korea

Environmental Monitoring and Assessment, 2004
This study assessed the daily exposure to dioxin using comparable approach methods in order to predict the human health risks of dioxin on the general adult population and incinerator workers in Korea. The health risk assessment of dioxin involved four scenarios (General-Direct, General-Breast Milk, General-Blood, and Worker-Blood).
Lim, Y, Yang, JY, Kim, Y, Chang, YS, Shin, DC   +4 more
openaire   +3 more sources

Pediatric Idiopathic Multicentric Castleman Disease Is Often Severe But Responsive to Siltuximab

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Idiopathic multicentric Castleman disease (iMCD) is a potentially fatal immunologic disorder marked by widespread lymphadenopathy and inflammation. Siltuximab, an interleukin‐6 (IL‐6) inhibitor, is the only FDA‐approved treatment for adult patients with iMCD.
Bridget Austin, Sheila K. Pierson, Kelley C. Dacus, Mateo Sarmiento Bustamante, Saishravan Shyamsundar, Larissa Borys, Kayla McHugh, Abiola Irvine, Yoojin Jo, Adam Bagg, Mary Jo Lechowicz, Daisy Alapat, Amy Chadburn, Megan S. Lim, Gordan Srkalovic, Frits van Rhee, David C. Fajgenbaum, Joshua D. Brandstadter   +17 more
wiley   +1 more source

Probabilistic integrated human mixture risk assessment of multiple metals through seafood consumption

, 2018
[[abstract]]Inorganic arsenic (iAs), cadmium (Cd), lead (Pb), and methylmercury (MeHg) are toxic metals that cause substantial health concern and are present in various seafood items.
Lin, YJ;Lin, P
core   +1 more source

The Impact of the COVID‐19 Pandemic on Childhood Cancer Survival: A Population‐Based Assessment of Survival Patterns Between 2015 and 2023 in Germany

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Numerous international studies have reported declines in new cancer diagnoses, delayed diagnoses and disruptions in cancer treatment following the implementation of COVID‐19 pandemic public health measures, raising concerns that these effects may ultimately contribute to increased cancer mortality.
Friederike Erdmann, Maike Wellbrock, Javier Louro, Arndt Borkhardt, Martin Schrappe, Claudia Trübenbach, Desiree Grabow, Cécile M. Ronckers, Joachim Schüz   +8 more
wiley   +1 more source

Quantitative evaluation of genotoxicity data for risk assessment and regulatory decision-making: Time for a paradigm shift

Environment International
Genotoxicity plays an important role in chemical safety assessment, as genetic alterations can lead to severe and irreversible health consequences. To date, the assessment of genotoxicity has mostly been limited to hazard identification, followed by ...
Benjamin Sachse, Sebastian Schmeisser, Jan van Benthem, Raffaella Corvi, Eugenia Dogliotti, Norman Ertych, Roland Frötschl, Ulrike Gündel, Kristin Herrmann, George Johnson, Carsten Kneuer, Jeannette König, Hans-Jörg Martus, Stefan Pfuhler, Stephanie Smith-Roe, Helga Stopper, Paul White, Tanja Schwerdtle, Andreas Hensel, Tewes Tralau   +19 more
doaj   +1 more source

Venetoclax‐Based Therapy as a Bridge to Hematopoietic Stem Cell Transplantation in Relapsed or Refractory Pediatric Acute Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Relapsed and/or refractory (R/R) pediatric acute leukemia carries a dismal prognosis, largely driven by chemoresistance to conventional salvage therapy. The BH3‐mimetic venetoclax, combined with chemotherapy or hypomethylating agents, has demonstrated efficacy in small clinical trials.
Katherine S. Colman, Deborah Meyran, Vajiranee Malalasekera, Heather Weerdenburg, Janine Campbell, Rachel Conyers, Stacie Wang, Hannah Walker, Seong Lin Khaw, Diane Hanna   +9 more
wiley   +1 more source