Results 1 to 10 of about 1,981,620 (219)
Characterization of Arabian Peninsula whole exomes: Contributing to the catalogue of human diversity
iScience, 2022 Summary: The cataloging of human genomic variation is a challenging task given the size and diversity of the global human population. Several geographic regions remain under-characterized, such as the Arabian Peninsula (AP), which is unique in being at ...
Joana C. Ferreira +3 more
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iScience, 2022 Summary: Slow oxidative muscle, most notably the soleus, is inherently well equipped with the molecular machinery for regulating blood-borne substrates.
Marc T. Hamilton +2 more
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MAP3K19 regulatory variation in populations with African ancestry may increase COVID-19 severity
iScience, 2023 Summary: To identify ancestry-linked genetic risk variants associated with COVID-19 hospitalization, we performed an integrative analysis of two genome-wide association studies and resolved four single nucleotide polymorphisms more frequent in COVID-19 ...
Zhongshan Cheng +7 more
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Estimated 24-h urinary sodium excretion and risk of end-stage kidney disease
iScience, 2023 Summary: The association between sodium intake and long-term kidney disease endpoints is debated and yet to be proven. We aimed to investigate the associations of estimated 24-h urinary sodium excretion, reflecting daily sodium intake, with the incidence
Ying Shan +11 more
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Overcoming cohort heterogeneity for the prediction of subclinical cardiovascular disease risk
iScience, 2023 Summary: Cardiovascular disease remains a leading cause of mortality with an estimated half a billion people affected in 2019. However, detecting signals between specific pathophysiology and coronary plaque phenotypes using complex multi-omic discovery ...
Adam S. Chan +7 more
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The Genetic contribution to solving the cocktail-party problem
iScience, 2022 Summary: Communicating in everyday situations requires solving the cocktail-party problem, or segregating the acoustic mixture into its constituent sounds and attending to those of most interest.
Samuel R. Mathias +15 more
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iScience, 2023 Summary: Body-mass index (BMI) is a hallmark of adiposity. In contrast with adulthood, the genetic architecture of BMI during childhood is poorly understood.
Lucas Vicuña +10 more
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Endogenous Metabolic Modulators: Emerging Therapeutic Potential of Amino Acids
iScience, 2020 Summary: Multifactorial disease pathophysiology is complex and incompletely addressed by existing targeted pharmacotherapies. Amino acids (AAs) and related metabolites and precursors are a class of endogenous metabolic modulators (EMMs) that have diverse
Michael J. Hamill +3 more
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Randomized controlled trial for time-restricted eating in overweight and obese young adults
iScience, 2022 Summary: Time-restricted eating (TRE) is known to improve metabolic health, whereas very few studies have compared the effects of early and late TRE (eTRE and lTRE) on metabolic health.
Li-min Zhang +14 more
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iScience, 2023 Summary: Cholesterol-to-coprostanol conversion by the intestinal microbiota has been suggested to reduce intestinal and serum cholesterol availability, but the relationship between intestinal cholesterol conversion and the gut microbiota, dietary habits,
Alena M. Bubeck +20 more
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