Results 11 to 20 of about 1,991,588 (267)

Randomized controlled trial for time-restricted eating in overweight and obese young adults

iScience, 2022
Summary: Time-restricted eating (TRE) is known to improve metabolic health, whereas very few studies have compared the effects of early and late TRE (eTRE and lTRE) on metabolic health.
Li-min Zhang, Zhan Liu, Jia-qi Wang, Rui-qiang Li, Jing-yi Ren, Xian Gao, Shuai-shuai Lv, Lu-yao Liang, Fan Zhang, Bo-wen Yin, Yan Sun, Hao Tian, Hui-chen Zhu, Yu-tian Zhou, Yu-xia Ma   +14 more
doaj   +1 more source

High-fat diet impact on intestinal cholesterol conversion by the microbiota and serum cholesterol levels

iScience, 2023
Summary: Cholesterol-to-coprostanol conversion by the intestinal microbiota has been suggested to reduce intestinal and serum cholesterol availability, but the relationship between intestinal cholesterol conversion and the gut microbiota, dietary habits,
Alena M. Bubeck, Paul Urbain, Cathrine Horn, Anna S. Jung, Lisa Ferrari, Hannah K. Ruple, Daniel Podlesny, Stefanie Zorn, Johnny Laupsa-Borge, Caroline Jensen, Inge Lindseth, Gülen Arslan Lied, Jutta Dierkes, Gunnar Mellgren, Hartmut Bertz, Silke Matysik, Sabrina Krautbauer, Gerhard Liebisch, Hans-Frieder Schoett, Simon N. Dankel, W. Florian Fricke   +20 more
doaj   +1 more source

Estimating the number of diseases – the concept of rare, ultra-rare, and hyper-rare

iScience, 2022
Summary: At the dawn of the personalized medicine era, the number of rare diseases has been estimated at 10,000. By considering the influence of environmental factors together with genetic variations and our improved diagnostic capabilities, an ...
C. I. Edvard Smith, Peter Bergman, Daniel W. Hagey   +2 more
doaj   +1 more source

Low-density lipoprotein receptor genotypes modify the sera metabolome of patients with homozygous familial hypercholesterolemia

iScience, 2022
Summary: Homozygous familial hypercholesterolemia (HoFH) is an extremely rare metabolism disorder usually caused by low-density lipoprotein receptor (LDLR) mutations.
Zhiyong Du, Fan Li, Linyi Li, Yu Wang, Jianping Li, Ya Yang, Long Jiang, Luya Wang, Yanwen Qin   +8 more
doaj   +1 more source

Neutrosophy and Health Sciences: a necessary alliance

Revista Información Científica, 2023
Health is the truth of life, it is a fundamental quality of the human being that is expressed in each of its four dimensions (biological, ecological, social and spiritual) and defines human nature.
Alfredo Pardo-Fernández, Yamilé Rodríguez-Sotomayor   +1 more
doaj   +1 more source

Federated generalized linear mixed models for collaborative genome-wide association studies

iScience, 2023
Summary: Federated association testing is a powerful approach to conduct large-scale association studies where sites share intermediate statistics through a central server. There are, however, several standing challenges.
Wentao Li, Han Chen, Xiaoqian Jiang, Arif Harmanci   +3 more
doaj   +1 more source

Cord serum metabolic signatures of future progression to immune-mediated diseases

iScience, 2023
Summary: Previous prospective studies suggest that progression to autoimmune diseases is preceded by metabolic dysregulation, but it is not clear which metabolic changes are disease-specific and which are common across multiple immune-mediated diseases ...
Tuulia Hyötyläinen, Bagavathy Shanmugam Karthikeyan, Tannaz Ghaffarzadegan, Eric W. Triplett, Matej Orešič, Johnny Ludvigsson   +5 more
doaj   +1 more source

A Genetic modification that reduces ON-bipolar cells in hESC-derived retinas enhances functional integration after transplantation

iScience, 2022
Summary: Pluripotent stem cell (PSC)-derived retinal sheet transplanted in vivo can form structured photoreceptor layers, contact with host bipolar cells, and transmit light signals to host retinas.
Suguru Yamasaki, Hung-Ya Tu, Take Matsuyama, Matsuri Horiuchi, Tomoyo Hashiguchi, Junki Sho, Atsushi Kuwahara, Akiyoshi Kishino, Toru Kimura, Masayo Takahashi, Michiko Mandai   +10 more
doaj   +1 more source

Probiotic Limosilactobacillus fermentum GR-3 ameliorates human hyperuricemia via degrading and promoting excretion of uric acid

iScience, 2022
Summary: Probiotics have demonstrated the potential to ameliorate hyperuricemia in animals, but their effectiveness and mechanism of action in humans has been understudied.
Shuai Zhao, Pengya Feng, Xiaogang Hu, Wenjuan Cao, Pu Liu, Huawen Han, Weilin Jin, Xiangkai Li   +7 more
doaj   +1 more source

Training effects of set- and repetition-interval rest time on recumbent-boxing exercise: Could virtual reality improve further?

iScience, 2023
Summary: This study examined the influence of set-interval and repetition-interval rest time of virtual reality (VR) boxing game in supine-lying posture.
Yi Wang, Qi Chen, Liangchao Liu, Qiuhong He, James Chung-Wai Cheung, Duo Wai-Chi Wong, Yang Liu, Wing-Kai Lam   +7 more
doaj   +1 more source