Results 241 to 250 of about 6,269,925 (357)

Addressing the elephant in the room: Proceedings of the third annual Dengue Endgame Summit. [PDF]

PLoS Negl Trop Dis
Bahr LE, Rothman AL, Barrett ADT, Buddhari D, Cummings DAT, Christofferson RC, Ko AI, Ooi EE, Anderson KB, Thomas SJ, Waickman AT.   +10 more
europepmc   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Paralytic rabies outbreak mimicking guillain-Barré syndrome in French Amazonia. [PDF]

PLoS Negl Trop Dis
Deschamps N, Mayence C, Parize P, Douine M, Montagnac C, Houcke S, Epelboin L, Nasri A, Djossou F, Larrous F, Worsley-Tonks K, Hamiche K, Monaya A, Rousseau C, Gavohedo S, Alsibai KD, Demar M, de Toffol B, Bourhy H, Kallel H.   +19 more
europepmc   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Geographic, demographic and economic burden of human cystic echinococcosis in Italy based on hospital discharge records (2015-2022). [PDF]

PLoS Negl Trop Dis
Bonelli P, Stegel G, Mastrandrea S, Masu G, Peruzzu A, Santucciu C, Masala G.   +6 more
europepmc   +1 more source

Discovery and technology for human health

Nature Biomedical Engineering, 2017

semanticscholar   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Intervention research to protect human health in the era of climate extremes. [PDF]

PLoS Med
Bärnighausen T, Lumbard H.
europepmc   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Testing the feasibility of blood flow restriction training to enhance the HEALTH benefits of exercise in individuals with type 2 diabetes (BOOST-HEALTH Trial): Study Protocol. [PDF]

PLoS One
Thomson AM, McCarthy SF, Burr JF, Little JP, Kebbe M, Sénéchal M.   +5 more
europepmc   +1 more source