Results 121 to 130 of about 8,817,949 (255)

Protective role of Galectin‐3 in prion disease through regulation of microglial PrPSc uptake

open access: yesBrain Pathology, EarlyView.
Galectin‐3 (Gal3) is induced in reactive microglia during prion disease and promotes microglial uptake of PrPSc. Gal3 deficiency reduces prion sequestration and accelerates disease progression, revealing a protective role for Gal3. Abstract Microglia constitute a major innate defense mechanism against prion infection; however, the molecular pathways ...
Natallia Makarava   +8 more
wiley   +1 more source

Novel approaches for drug development against chronic primary pain: A systematic review

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus   +5 more
wiley   +1 more source

Risk of HSV-2 Acquisition Among Women with Bacterial Vaginosis: Systematic Review and Meta-Analysis

open access: yesViruses
Objective: Bacterial vaginosis is a dysbiosis of the vaginal microbiome, typically characterized by a loss of Lactobacillus. Lactobacillus plays a crucial role in vaginal immunity and protection against sexually transmitted infections.
Taylor N. Whitt   +4 more
doaj   +1 more source

HERPES-SIMPLEX VIRUS FROM TRIGEMINAL GANGLION

open access: yes, 1973
HERPES-SIMPLEX VIRUS FROM TRIGEMINAL ...
DO WHITE (14583035)   +2 more
core  

Therapeutic potential of natural products in cancer immunotherapy: Advances and challenges

open access: yesBritish Journal of Pharmacology, EarlyView.
This review systematically outlines the mechanisms underlying tumour immunotherapy resistance and elucidates the role of natural products in enhancing therapeutic efficacy as immunomodulatory adjuvants. Abstract Immunotherapy has emerged as a clinically pivotal approach in cancer treatment, but its application remains limited to a small subset of ...
Rao Hu   +6 more
wiley   +1 more source

So many scenarios in herpetic eye disease

open access: yesUkrainian Journal of Ophthalmology
Human herpes infections are a major cause of morbidity worldwide. Herpes Simplex Virus (HSV) and Varicella Zoster Virus (VZV) are frequent causes of ocular pathology.
Petja Vassileva, Yordanka Kirilova
doaj   +1 more source

Peripheral targets for neuropathic pain

open access: yesBritish Journal of Pharmacology, EarlyView.
Neuropathic pain represents a significant clinical challenge, with still limited pharmacological approaches to symptomatic relief. This review focuses on molecular targets implicated in neuropathic pain, particularly those involved in peripheral mechanisms. Using the IUPHAR/BPS database of biological targets, their occurrence together with ‘neuropathic
Amirhossein Afsharipour   +3 more
wiley   +1 more source

Human Herpes Virus 7-related encephalopathy in children. [PDF]

open access: yesActa Biomed, 2022
Foiadelli T   +9 more
europepmc   +1 more source

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