Results 241 to 250 of about 244,434 (305)

IgA Antibodies Reveal Covert Infection With Mpox Virus in People Living With HIV in the Community: A Prospective Longitudinal Cohort Survey

open access: yesMedComm, Volume 7, Issue 4, April 2026.
This study identified covert infection of MPXV among people living with HIV and MPXV‐IgA was the effective indicator. The combined use of two antigen protein set of MPXV (B6R plus E8L and E8L plus H3L) yield IgA test results comparable to those obtained with the MPXV.
Rui Song   +12 more
wiley   +1 more source

Enhancing Oncolytic Adenovirus Replication by Early Region 1A Protein‐Mediated Degradation of E1A Binding Protein p300

open access: yesMedComm, Volume 7, Issue 4, April 2026.
E1A is an important protein for adenovirus to initiate viral replication. Previous reports have shown that E1A binds to p300 as a regulatory factor. However, our study provides a new perspective that E1A promotes oncolytic adenovirus replication by degrading p300.
Boduan Xiao   +7 more
wiley   +1 more source

Unraveling Chronic Pain: From Mechanisms and Risks to Diagnosis and Treatment

open access: yesMedComm, Volume 7, Issue 4, April 2026.
Chronic pain arises through distinct molecular pathways categorized into nociceptive, neuropathic, and nociplastic types. Nociceptive pain begins with TRP channel activation in peripheral nociceptors, signaling via Aδ‐ and C‐fibers through the spinal dorsal horn and spinothalamic tracts to the brain, regulated by descending inhibition and involving ...
Xiaofeng Dai   +3 more
wiley   +1 more source

Immunocompromised Status Definition in Observational Studies Using Electronic Health Records: A Scoping Review and a Proposal for a Phenotype Identification Algorithm

open access: yesPharmacoepidemiology and Drug Safety, Volume 35, Issue 4, April 2026.
ABSTRACT Immunocompromised individuals experience an impaired immune function due to conditions that might be either congenital or acquired over the course of their lives. Epidemiological studies often rely on clinical definitions which, in some cases, benefit from being translated into machine‐readable algorithms for application to electronic health ...
Judit Riera‐Arnau   +62 more
wiley   +1 more source

Placental insufficiency markers to assess the risk of non‐chromosomal genetic conditions in early‐onset fetal growth restriction

open access: yesUltrasound in Obstetrics &Gynecology, Volume 67, Issue 4, Page 492-499, April 2026.
ABSTRACT Objectives To assess the value of placental insufficiency markers for estimating the risk of genetic anomalies in fetuses with isolated early‐onset fetal growth restriction (FGR), defined as an estimated fetal weight ≤ 3rd percentile diagnosed ≤ 28 + 6 weeks' gestation.
M. Armengol‐Alsina   +17 more
wiley   +1 more source

Simulated Microgravity Causes Faster Replication During Acute Infection of ME49‐Toxoplasma Gondii and Alterations in Host Cells

open access: yesFASEB BioAdvances, Volume 8, Issue 4, April 2026.
Simulated microgravity (SMG) alters the growth and morphology of host cells and induces parasite replication during acute T. gondii infection. In this study, we examined host cells and Type II T. gondii using a 3D clinostat. Increased number of host cells and multicellular spheroids observed in Vero cells and HFF.
Musfika Tasnim Shirin   +8 more
wiley   +1 more source

Adenovirus‐Associated Opsoclonus After Allogeneic Hematopoietic Stem Cell Transplantation

open access: yes
eJHaem, Volume 7, Issue 2, April 2026.
Toru Miyajima   +5 more
wiley   +1 more source

Repeated injection of pooled frozen allogeneic umbilical cord blood mesenchymal stromal cells in 5 flat‐racing horses

open access: yesEquine Veterinary Education, Volume 38, Issue 4, Page 183-194, April 2026.
Summary Background Tendinopathies in racehorses are challenging to treat, and restoring normal tendon composition remains elusive despite extensive research. Equine multipotent mesenchymal stromal cells (MSC) have shown promise for tendon repair, and various sources of MSC have been described.
A. Merchan Muñoz   +7 more
wiley   +1 more source

Impact of the BioFire FilmArray Meningitis‐Encephalitis Panel on Management of Suspected Paediatric Central Nervous System Infections: A Single‐Centre Retrospective Cohort Study

open access: yesJournal of Paediatrics and Child Health, Volume 62, Issue 4, Page 586-593, April 2026.
ABSTRACT Background Meningoencephalitis causes significant morbidity and mortality in children worldwide. Prompt diagnosis remains challenging, yet advances in molecular diagnostic technology have improved diagnostic performance. This study examined whether the introduction of the BioFire FilmArray meningitis/encephalitis (ME) multiplex panel impacted ...
Louisa Mary Churcher   +4 more
wiley   +1 more source

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