Results 61 to 70 of about 8,405,379 (306)

Human herpes simplex virus keratitis: the pathogenesis revisited [PDF]

Ocular Immunology and Inflammation, 2004
Infections with several members of the human herpesviruses are the cause of significant ocular morbidity. Of the human herpesviruses, HSV-1 is the most frequent cause of primary and recurrent eye disease. Despite the availability of effective antiviral treatment, recurrent HSV-1 infection continues to be the leading cause of corneal blindness in ...
Remeijer, L (Lies), Osterhaus, Ab, Verjans, Georges   +2 more
openaire   +2 more sources

Population-level effect of potential HSV2 prophylactic vaccines on HIV incidence in sub-Saharan Africa. [PDF]

, 2009
Herpes simplex virus type-2 (HSV2) infection increases HIV transmission. We explore the impact of a potential prophylactic HSV2 vaccination on HIV incidence in Africa using STDSIM an individual-based model.
Orroth, K. K., Buve, A, Hayes, Richard J., Weiss, Helen A, Hayes, R. J., Glynn, Judith R., Glynn, Judith R, Weiss, H. A., White, Richard G, Hayes, Richard J, White, Richard G., Bakker, R., Weiss, Helen A., Orroth, Kate K, Buvé, Anne, Freeman, EE, Glynn, J. R., Weiss, HA, White, R. G., Freeman, Esther E, Freeman, Esther E., Freeman, E. E., Buvé, A., White, RG, Glynn, JR, Orroth, KK, Orroth, Kate K., Bakker, Roel, Hayes, RJ   +28 more
core   +1 more source

Deltacoronavirus Modulates circRNA cGLIS3 Metabolism to Evade Host Antiviral Response

Advanced Science, EarlyView.
This study reveals that both deltacoronavirus nucleocapsid protein and host RNA binding protein IGF2BP2 promote circular RNA GLIS3 (cGLIS3) biogenesis by binding to GLIS3 pre‐mRNA. The m6A modification‐mediated cGLIS3‐IGF2BP2 interaction weakens RNase L‐mediated degradation of cGLIS3 while facilitates a ubiquitin‐dependent degradation of IGF2BP2, thus ...
Liuyang Du, Liping Wang, Sujing Diao, Juan Li, Lei Zhao, Yan Yan, Haimin Li, Weiren Dong, Wei Wu, Jinyan Gu, Jiyong Zhou   +10 more
wiley   +1 more source

CAQ Corner: Immune‐mediated complications

, 2022
Liver Transplantation, EarlyView.
Mary Thomson, John R. Lake
wiley   +1 more source

Herpes simplex virus 1 rhombencephalitis in a patient with chromosomally integrated human herpesvirus-6A

IDCases, 2020
Central nervous system infection caused by Herpes simplex virus 1 remains a significant cause of morbidity and mortality in transplant patients. Additionally, the clinical implications of the recently discovered Human herpesvirus 6A are still under ...
Raquel Silva, Vitor Duque, Rita Magano, Luís Trindade   +3 more
doaj   +1 more source

EBV‐Driven ODC1 Upregulation Enhances Polyamine Anabolism to Promote Viral Replication and Cisplatin Resistance in Nasopharyngeal Carcinoma

Advanced Science, EarlyView.
EBV‑BZLF1 initiates ODC1‑driven polyamine anabolism that correlates with poor clinical prognosis in nasopharyngeal carcinoma. The ODC1–spermidine axis promotes viral replication, cell proliferation and innate immune evasion. Pharmacological inhibition of ODC1 rescues cisplatin sensitivity, establishing ODC1 as a viable therapeutic target for EBV ...
Yueshuo Li, Xudong Hu, Chenxing Yang, Na Liu, Lin Wang, Xi Cai, Min Tang, Ya Cao, Li Shang, Feng Shi   +9 more
wiley   +1 more source

Kaposi’s Sarcoma-associated Herpesvirus

Berkala Ilmu Kesehatan Kulit dan Kelamin (Periodical of Dermatology and Venerology), 2016
Background: Kaposi’s sarcoma (KS) revealed by Moritz Kaposi first time in 1872. In the early 1980, the prevalence of SK began to increase dramatically.
Novia Indriyani Adisty, Sawitri Sawitri, Willy Sandhika   +2 more
doaj   +1 more source

Herpes simplex virus in the human cornea [PDF]

British Journal of Ophthalmology, 2000
Herpes simplex virus (HSV) infection is prevalent throughout the world. An estimated 60–70% of children aged 5 and close to 90% of adults exhibit seropositivity (neutralising antibody) to HSV antigens. Despite this widespread prevalence, only 20%–30% present with clinical disease, and ocular manifestations develop in less than 1%.1 Traditionally, the
openaire   +1 more source

Risk factors for herpes simplex virus type 2 and HIV among women at high risk in northwestern Tanzania: preparing for an HSV-2 intervention trial. [PDF]

, 2007
OBJECTIVES: To determine prevalence of and risk factors for herpes simplex virus type 2 (HSV-2) and HIV among women being screened for a randomized, controlled trial of HSV suppressive therapy in northwestern Tanzania. METHODS: Two thousand seven hundred
Mugeye, Kokugonza, Hayes, Richard J, Balira, Rebecca, Knight, Louise, Ross, David, Changalucha, John, Weiss, Helen A, Baisley, Kathy, Watson-Jones, Deborah, Rusizoka, Mary, Everett, Dean   +10 more
core   +1 more source

Uncoupling Type I Interferon Benefits From Inflammatory Toxicity: Transformer‐Prioritized Precision Agonists for Potent and Safer Cancer Immunotherapy

Advanced Science, EarlyView.
A Transformer‐based AI framework, DLINP, screens millions of compounds to identify Co68, a cobalt‐pincer organometallic complex that biases TLR4‐MD2 signaling toward antitumor interferon activation while suppressing inflammatory toxicity through an early TLR4‐SYK‐STAT1 axis.
Xuefei Guo, Yang Zhao, Xianle Rong, Xingyu Chen, Xiao Wang, Tianyi Liu, Yunfei Xie, Yushu Zou, Pingsen Zhao, Qiang Liu, Fuping You   +10 more
wiley   +1 more source