Results 51 to 60 of about 650,298 (204)
The battle between the innate immune cGAS-STING signaling pathway and human herpesvirus infection
Frontiers in Immunology, 2023 The incidence of human herpesvirus (HHVs) is gradually increasing and has affected a wide range of population. HHVs can result in serious consequences such as tumors, neonatal malformations, sexually transmitted diseases, as well as pose an immense ...
Ximing Jin +8 more
doaj +1 more source
The strong enhancer element in the immediate early region of the human cytomegalovirus genome [PDF]
, 1985 The human cytomegalovirus (HCMV), a member of the herpesvirus group, was found to possess a strong transcription enhancer in the immediate early gene region. Co-transfection of enhancerless SV40 DNA with randomly fragmented HCMV DNA yielded two SV40-
Boshart, Michael +9 more
core +1 more source
Human herpesvirus 6 and human herpesvirus 7 in chronic fatigue syndrome [PDF]
Journal of Clinical Microbiology, 1995 We analyzed lymphocytes of patients with chronic fatigue syndrome (CFS) for the presence of human herpesvirus 6 (HHV-6) and HHV-7 DNA. HHV-7 was present in over 80% of CFS patients and healthy controls, while the prevalence of HHV-6 variant A increased significantly in CFS cases (22 versus 4%; P = 0.05).
DI LUCA, Dario +5 more
openaire +3 more sources
Evidence for Tethering of Human Cytomegalovirus Genomes to Host Chromosomes
Frontiers in Cellular and Infection Microbiology, 2020 Tethering of viral genomes to host chromosomes has been recognized in a variety of DNA and RNA viruses. It can occur during both the productive cycle and latent infection and may impact viral genomes in manifold ways including their protection ...
Katrin Mauch-Mücke +3 more
doaj +1 more source
Kaposi’s sarcoma associated with chronic myeloid leukemia and imatinib mesylate therapy
Clinical Case Reports, 2022 Kaposi's sarcoma is associated with immunosuppression and human herpesvirus 8 infection, while rarely described in myeloid malignancies. Here, we illustrate a rare case of chronic myeloid leukemia treated with imatinib, a tyrosine kinase inhibitor, who ...
Matteo D’Addona +6 more
doaj +1 more source
Targeting the ATP-dependent formation of herpesvirus ribonucleoprotein particle assembly as an antiviral approach [PDF]
, 2016 Human herpesviruses are responsible for a range of debilitating acute and recurrent diseases, including a number of malignancies. Current treatments are limited to targeting the herpesvirus DNA polymerases, however with emerging viral resistance and ...
Foster, R +6 more
core +1 more source
Viruses, 2016 Human herpesvirus-6A and B (HHV-6A, HHV-6B) have recently defined endogenous genomes, resulting from integration into the germline: chromosomally-integrated “CiHHV-6A/B”.
Joshua Tweedy +5 more
doaj +1 more source
A systematic review of the impact of psychosocial factors on immunity: Implications for enhancing BCG response against tuberculosis. [PDF]
, 2019 Background: Tuberculosis (TB) remains an urgent global public health priority, causing 1.5 million deaths worldwide in 2018. There is evidence that psychosocial factors modulate immune function; however, how this may influence TB risk or BCG vaccine ...
Boccia, D +5 more
core +2 more sources
Bortezomib promotes KHSV and EBV lytic cycle by activating JNK and autophagy [PDF]
, 2017 KSHV and EBV are gammaherpesviruses strictly linked to human cancers. Even if the majority of cancer cells harbor a latent infection, the few cells that undergo viral replication may contribute to the pathogenesis and maintenance of the virus-associated ...
Cirone, Mara +7 more
core +2 more sources
mBio, 2017 Kaposi’s sarcoma-associated herpesvirus (KSHV) is associated with the human malignancy Kaposi’s sarcoma and the lymphoproliferative disorders primary effusion lymphoma and multicentric Castleman’s disease. KSHV establishes lytic infection of monocytes in
Kurtis M. Host +7 more
doaj +1 more source