Results 131 to 140 of about 387 (176)

Synthesis of 4-oxo-4,7-dihydrofuro[2,3-b]pyridine-5-carboxamides with broad-spectrum human herpesvirus polymerase inhibition

Bioorganic & Medicinal Chemistry Letters, 2008
A versatile synthesis of 4-oxo-4,7-dihydrofuro[2,3-b]pyridine-5-carboxylate esters has been developed which has lead to the identification of a new series of non-nucleoside inhibitors of human herpesvirus polymerases HCMV, HSV-1, EBV, and VZV with high specificity compared to human DNA polymerases.
Mark E, Schnute, Roger J, Brideau, Sarah A, Collier, Michele M, Cudahy, Todd A, Hopkins, Mary L, Knechtel, Nancee L, Oien, Robert S, Sackett, Allen, Scott, Mari L, Stephan, Michael W, Wathen, Janet L, Wieber   +11 more
openaire   +2 more sources

Activating transcription factor 4 (ATF4) is upregulated by human herpesvirus 8 infection, increases virus replication and promotes proangiogenic properties

Archives of Virology, 2011
Human herpesvirus 8 (HHV-8) triggers proangiogenic behaviour in endothelial cells by inducing monocyte chemoattractant protein 1 (MCP-1) through activation of Nuclear Factor κB (NF-κB). However, NF-κB inhibition still results in partial MCP-1 induction and consequent angiogenesis, suggesting the involvement of another transcriptional pathway.
CASELLI, Elisabetta, BENEDETTI, Sabrina, GRIGOLATO, Jessica, Caruso A., DI LUCA, Dario   +4 more
openaire   +3 more sources

Tim-1 and Tim-4 mediate entry of the human Kaposi’s sarcoma-associated herpesvirus and the related rhesus monkey rhadinovirus

2023
ABSTRACT Kaposi’s sarcoma-associated herpesvirus (KSHV) is a human tumor virus. It is associated with Kaposi’s sarcoma, primary effusion lymphoma, and multicentric Castleman’s disease. KSHV is known to interact with several different receptors, among them heparan sulfate proteoglycans, Eph family receptors, and integrins. We mutated the
Stefano Scribano, Sarah Schlagowski, Shanchuan Liu, Thomas Fricke, Xiaoliang Yang, Frank Neipel, Anna K. Großkopf, Bojan F. Hörnich, Marija Backovic, Armin Ensser, Alexander S. Hahn   +10 more
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DIAGNOSIS OF AN ALLERGIC REACTION TO ANTIBIOTICS IN AN PATIENT WITH ACTIVE HUMAN HERPESVIRUS -4, -6 TYPE INFECTION (CLINICAL CASE).

Georgian medical news, 2022
Beta-lactam antibiotics (BLAs) can provoke drug hypersensitivity reactions, particularly delayed-type reactions. This article presents a case of drug allergy with manifestations of Stevens-Johnson syndrome (SJD) in a 42-year-old man with yersiniosis and active herpesvirus -4, -6 type, who received amoxacillin with clavulanic acid. The patient underwent
S, Zubchenko, A, Havrylyuk, M, Lomikovska, I, Kril, S, Chuiko   +4 more
openaire   +1 more source

Identification of a novel septin 4 protein binding to human herpesvirus 8 kaposin A protein using a phage display cDNA library

Journal of Virological Methods, 2007
Human herpesvirus 8 (HHV-8) is associated with the development of Kaposi's sarcoma and several other human malignancies. Kaposin A protein of HHV-8 has been demonstrated as inducing tumorigenic transformation, being responsible for nuclear receptor coactivators in the transforming activity.
Cheng-Wen, Lin, Ping-Feng, Tu, Nai-Wan, Hsiao, Ching-Yao, Chang, Lei, Wan, Yu-Tsun, Lin, Hsueh-Wei, Chang   +6 more
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Effect of IL‐12 and soluble IL‐4 receptor on the herpesvirus infection in human SCID chimeras whose Th2 cells predominate

Immunology & Cell Biology, 2004
Th2 cytokines, commonly detected in burn patients, have been shown as inhibitors for the generation of Th1 cells that are essential for the host's resistance against herpes simplex virus type 1 (HSV‐1) infection. In this study, the possibility of immunological treatment through the regulation of Th1/Th2 responses was examined in two kinds of human ...
Tatsushi, Katakura, Makiko, Kobayashi, David N, Herndon, Fujio, Suzuki   +3 more
openaire   +2 more sources

4: Complete replication cycle and acquisition of tegument in nucleus of human herpesvirus 6A (HHV-6A) in astrocytes and in T-cells

Journal of Clinical Virology, 2006
The ultrastructural replication cycle of human herpesvirus 6A and 6B, both T-lymphotropic viruses, with tropism for the central nervous system,wascomparedbyelectronmicroscopyin the same cells, that is, in the T-lymphoblastoid cell line SupT-1 and in human astrocytes.
J. Ahlqvist, D. Donati, E. Martinelli, N. Akhyani, J. Hou, E.O. Major, S. Jacobson, A. Fogdell-Hahn   +7 more
openaire   +1 more source

Biologically significant interaction of human herpesvirus 8 viral interferon regulatory factor 4 with ubiquitin-specific protease 7

Journal of Virology
ABSTRACT Human herpesvirus 8 (HHV-8), associated with Kaposi sarcoma, primary effusion lymphoma (PEL), and multicentric Castleman disease, encodes four interferon regulatory factor homologs, vIRFs 1–4, that interact with and inhibit various mediators of host-cell defense against virus infection.
Zunlin Yang, John Nicholas
openaire   +2 more sources

2-Aryl-2-hydroxyethylamine substituted 4-oxo-4,7-dihydrothieno[2,3-b]pyridines as broad-spectrum inhibitors of human herpesvirus polymerases

Bioorganic & Medicinal Chemistry Letters, 2007
A novel series of 2-aryl-2-hydroxyethylamine substituted 4-oxo-4,7-dihydrothieno[2,3-b]pyridine-5-carboxamides have been identified as potent antivirals against human herpesviruses. These compounds demonstrate broad-spectrum inhibition of the herpesvirus polymerases HCMV, HSV-1, EBV, and VZV with high specificity compared to human DNA polymerases.
Mark E, Schnute, David J, Anderson, Roger J, Brideau, Fred L, Ciske, Sarah A, Collier, Michele M, Cudahy, MariJean, Eggen, Michael J, Genin, Todd A, Hopkins, Thomas M, Judge, Euibong J, Kim, Mary L, Knechtel, Sajiv K, Nair, James A, Nieman, Nancee L, Oien, Allen, Scott, Steven P, Tanis, Valerie A, Vaillancourt, Michael W, Wathen, Janet L, Wieber   +19 more
openaire   +2 more sources

Human Herpesvirus-4 (HHV-4)

2013
Sheina Orbell, Havah Schneider, Sabrina Esbitt, Jeffrey S. Gonzalez, Jeffrey S. Gonzalez, Erica Shreck, Abigail Batchelder, Yori Gidron, Sarah D. Pressman, Emily D. Hooker, Deborah J. Wiebe, Deborah Rinehart, Laura L. Hayman, Luigi Meneghini, Hiroe Kikuchi, Hiroe Kikuchi, Tamer F. Desouky, Lisa M. McAndrew, Pablo A. Mora, Bonnie Bruce, Tana M. Luger, Peter Allebeck, Peter Allebeck, Peter Allebeck, Olveen Carrasquillo, Alfred L. McAlister, Kristine M. Molina, Stephen Birch, Amiram Gafni, Linda C. Baumann, Alyssa Karel, Howard Sollins, Catharina Hjortsberg, Lee Sanders, Yori Gidron, Erin N. Marcus, Olveen Carrasquillo, Vincent Tran, Peter Allebeck, Maartje Wit, Tibor Hajos, Yori Gidron, Sheah Rarback, Margaret Wallhagen, Margaret Wallhagen, Siqin Ye, Jonathan Newman, William Whang, Mark Hamer, Timothy W. Smith, Scott DeBerard, Peter A. Shapiro, Yoichi Chida, Valerie Sabol, Annie T. Ginty, Julian F. Thayer, Yoshinobu Kanda, Jonathan Newman, Carrie Brintz, Timothy Whittaker, Jennifer Wessel, Laura Rodriguez-Murillo, Rany M. Salem, Yutaka Matsuyama, J. Rick Turner, Neil Schneiderman, John Ruiz, Mariana Garza, Lauren Smith, Scott DeBerard, Nicole Overstreet, Jason W. Mitchell, Olveen Carrasquillo, Osvaldo Rodriguez, Jens Gaab, Siqin Ye, Laura Rodriguez-Murillo, Rany M. Salem, Yori Gidron, Oliver T. Wolf, Andrea Croom, Hollie B. Pellosmaa, Tamer F. Desouky, Steven C. Palmer, Kimberly M. Henderson, Susan A. Everson-Rose, Cari J. Clark, Susan A. Everson-Rose, Cari J. Clark, Kimberly M. Henderson, Susan A. Everson-Rose, Cari J. Clark, Kimberly M. Henderson, Kimberly M. Henderson, Susan A. Everson-Rose, Cari J. Clark, Jonathan Z. Bakdash, Frank A. Drews, Rany M. Salem, Laura Rodriguez-Murillo, Luis I. García, Lynnee Roane, Michael James Coons, Alyssa Parker, Kelly Flannery, Douglas Carroll, Leah Rosenberg, Molly S. Clark, Katherine T. Fortenberry, Kate L. Jansen, Alyssa Parker, Jennifer Heaney, Elliott A. Beaton, J. Rick Turner   +113 more
openaire   +1 more source