Results 41 to 50 of about 601,020 (224)

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Sensitive detection systems for infectious agents in xenotransplantation*

Xenotransplantation, EarlyView., 2020
Abstract Xenotransplantation of pig cells, tissues, or organs may be associated with transmission of porcine microorganisms, first of all of viruses, to the transplant recipient, potentially inducing a disease (zoonosis). I would like to define detection systems as the complex of sample generation, sample preparation, sample origin, time of sampling ...
Joachim Denner
wiley   +1 more source

Epstein-Barr virus: general factors, virus-related diseases and measurement of viral load after transplant

Revista Brasileira de Hematologia e Hemoterapia, 2011
The Epstein-Barr virus is responsible for infectious mononucleosis syndrome and is also closely associated to several types of cancer. The main complication involving Epstein-Barr virus infection, both in recipients of hematopoietic stem cells and solid ...
Luciana Cristina Fagundes Gequelin, Irina N Riediger, Sueli M Nakatani, Alexander W Biondo, Carmem M Bonfim   +4 more
doaj   +1 more source

Bovine herpesvirus 4-based vector delivering a hybrid rat/human HER-2 oncoantigen efficiently protects mice from autochthonous Her-2⁺mammary cancer [PDF]

OncoImmunology, 2015
The epidermal growth factor receptor 2 (HER-2) oncogene is a major target for the immunotherapy of breast cancer. Following up to the therapeutic success achieved with Her-2-targeting monoclonal antibodies, immune-prophylactic approaches directed against Her-2 have also been investigated taking into account, and trying to overcome, Her-2 self-tolerance.
Jacca, Sarah, ROLIH, VALERIA, QUAGLINO, Elena, Franceschi, Valentina, Tebaldi, Giulia, BOLLI, ELISABETTA, Rosamilia, Alfonso, Ottonello, Simone, CAVALLO, Federica, Donofrio, Gaetano   +9 more
openaire   +3 more sources

Hepatopulmonary syndrome as presentation of pediatric metabolic dysfunction‐associated steatohepatitis

JPGN Reports, EarlyView.
Abstract Childhood obesity is rising and leading to serious co‐morbidities, among which is metabolic dysfunction‐associated steatotic liver disease (MASLD) predisposing individuals to cirrhosis. We describe a young 11‐year‐old Hispanic male who presented with hepatopulmonary syndrome secondary to cirrhotic portal hypertension from metabolic dysfunction‐
Shruti Sakhuja, Stacey S. Beer, Kalyani R. Patel, Alexiss M. Williams, Nhu Thao Galvan, John A. Goss, Krupa R. Mysore   +6 more
wiley   +1 more source

Upper Airway Obstruction due to Kaposi Sarcoma—Presenting Sign of HIV: Case Report and Review

The Laryngoscope, EarlyView.
This study presents a case of undiagnosed HIV presenting with Kaposi sarcoma (KS) of the head and neck with acute upper airway obstruction (UAO) and provides an updated scoping literature review to examine the patient characteristics, lesion characteristics, interventions, and outcomes of KS cases with UAO from the pharynx, larynx, and/or trachea.
Zachary A. Wykoff, Logan F. McColl, Robert A. Baiocchi, Matthew O. Old   +3 more
wiley   +1 more source

Herpesvirus infections in ARVI episodes in children [PDF]

РМЖ. Мать и дитя, 2023
T.A. Ruzhentsova1,2, R.V. Popova3, A.A. Garbuzov1, E.K. Shushakova4, I.N. Khalyastov2,5, N.A. Meshkova6 1G.N. Gabrichevsky Moscow Research Institute of Epidemiology and Microbiology of the Federal Service for the Oversight of Consumer Protection ...
T.A. Ruzhentsova, R.V. Popova, A.A. Garbuzov, E.K. Shushakova, I.N. Khalyastov, N.A. Meshkova   +5 more
doaj  

Kaposiform hemangioendothelioma: Diagnosis and treatment

Pediatric Investigation, EarlyView.
Vascular endothelial growth factor‐C (VEGF‐C)/vascular endothelial growth factor receptor‐3 (VEGFR‐3) and angiopoietin‐2 (Ang‐2)/tyrosine kinase with immunoglobulin‐like and EGF‐like domain 2 (TIE2) signaling pathways play an important role in lymphangiogenesis.
Yi Tian, Yuanyuan Tian, Li Wei, Zigang Xu, Li Li, Lin Ma   +5 more
wiley   +1 more source

Mining metagenomes and metatranscriptomes unveils viruses associated with cutaneous squamous cell carcinoma in hematopoietic stem cell transplant recipients

Microbiology Spectrum
We investigated the presence of viral DNA and RNA in cutaneous squamous cell carcinoma (cSCC) tumor and normal tissues from nine individuals with a history of hematopoietic stem cell transplantation (HCT).
Jana K. Dickter, Yuqi Zhao, Vishwas Parekh, Huiyan Ma, Badri G. Modi, Wai-Yee Li, Saro H. Armenian, Xiwei Wu, Farah R. Abdulla   +8 more
doaj   +1 more source

Usefulness of Herpes Consensus PCR methodology to routine diagnostic testing for herpesviruses infections in clinical specimens

Virology Journal, 2007
The purposes of the study were to assess the usefulness of simultaneously amplifying herpes simplex virus 1 and 2, varicella-zoster virus, cytomegalovirus, Epstein-Barr virus and human herpesvirus 6 DNA in various clinical specimens and to analyze ...
Priavali Efthalia, Gartzonika Constantina, Kalogeropoulos Christos, Vrioni Georgia, Levidiotou Stamatina   +4 more
doaj   +1 more source