Results 51 to 60 of about 575,450 (284)

Cerebrospinal Fluid Metabolome in Central Nervous System Infections: A Study of Diagnostic Accuracy

Annals of Neurology, EarlyView.
Objective To assess the diagnostic accuracy of metabolites in cerebrospinal fluid (CSF) for central nervous system (CNS) infections. Methods Patients were derived from three prospective cohort studies in the Netherlands. All studies included adults suspected of a CNS infection who underwent a diagnostic lumbar puncture.
Steven L. Staal, Sabine E. Olie, Michel van Weeghel, Bauke V. Schomakers, Frédéric M. Vaz, I‐PACE Study Group, Diederik van de Beek, Matthijs C. Brouwer   +7 more
wiley   +1 more source

Prevalence of human herpesvirus 8 infection in patients undergoing hemodialysis using nested-PCR

Journal of Acute Disease, 2019
Objective: To study the prevalence of HHV-8 infection in patients undergoing hemodialysis. Methods: In this study, blood samples of 89 patients undergoing hemodialysis were collected.
Somayeh Shokri, Shahab Mahmoudvand, Manoochehr Makvandi, Toran Shahani, Ali Samadi, Heshmatollah Shahbazian   +5 more
doaj   +1 more source

Expert Perspective: Diagnosis and Treatment of Castleman Disease

Arthritis &Rheumatology, Accepted Article.
Summary Castleman disease (CD) is a major diagnostic challenge for Rheumatologists. Unicentric CD (UCD) involves one enlarged lymph node region whereas multicentric CD (MCD) involves multiple enlarged lymph node regions. Both UCD and MCD may exhibit a wide range of symptoms that overlap with other immune‐mediated conditions.
Luke Y.C. Chen, Lu Zhang, David C. Fajgenbaum   +2 more
wiley   +1 more source

Harvesting AAV by tangential flow filtration using reverse asymmetric membranes

Biotechnology Progress, EarlyView.
Abstract Efficient bioreactor clarification for harvesting virus particles is often challenging. Tangential flow filtration is attractive as it can be easily adapted for batch and perfusion operations. Here the feasibility of using reverse asymmetric hollow fiber membranes, where the more open support structure faces the feed stream, has been ...
Xiaolei Hao, Ronny Horax, Xianghong Qian, April Wheeler, Hironobu Shirataki, S. Ranil Wickramasinghe   +5 more
wiley   +1 more source

HIV-negative disseminated Kaposi’s sarcoma in a Taiwanese patient

Kaohsiung Journal of Medical Sciences, 2011
Kaposi’s sarcoma is a common malignancy associated with HIV/AIDS. Herein, we describe the case of a 26-year-old man who presented with bilateral neck and inguinal lymphadenopathy, a massive tumor on the gum, and a nodule over the left eye.
Chiung-Tang Huang, Chao-Sung Chang, Hung-Chune Maa, Shih-Feng Cho, Ta-Chih Liu   +4 more
doaj   +1 more source

Developing FGF2 Mutants with Selectively Reduced Heparan Sulfate Affinity to Explore Their Impact on FGFR1 Signaling

ChemBioChem, Accepted Article.
Fibroblast growth factor 2 (FGF2) regulates signal transduction by forming complexes with its receptors, FGF receptors (FGFRs), and heparan sulfate (HS), playing a crucial role in biological systems. Although HS has been suggested to modulate FGF/FGFR signaling as a co‐receptor, multiple hypotheses exist regarding how HS affects FGF/FGFR signaling, and
Yuga Okada, Akihiro Eguchi, Daisuke Kuroda, Kouhei Tsumoto, Ryosuke Ueki, Shinsuke Sando   +5 more
wiley   +1 more source

A rare histologic variant of Kaposi’s sarcoma

Revista da Sociedade Portuguesa de Dermatologia e Venereologia, 2023
An 80-year-old male presented with a 3-year history of progressive violaceous and edematous plaques on both hands. The remaining physical examination was unremarkable and systemic symptoms were absent.
Ana S. Pereira, Carolina Figueiredo, Rebeca Calado, José C. Cardoso   +3 more
doaj  

Targeting Ubiquitin‐Specific Protease 7 with Novel 5‐Amino‐Pyrazole Inhibitors: Design, Synthesis, and Biological Evaluation

ChemMedChem, EarlyView.
Ubiquitin‐specific protease 7 (USP‐7) is a novel target for anticancer therapy. To further extend the structure–activity relationships of the previously USP‐7 inhibitor STIRUR‐41, a library of 5‐aminopyrazoles is reported. 1d shows a potency comparable to lead compound STIRUR‐41 and promising in silico and in vitro pharmacokinetic properties ...
Matteo Lusardi, Elva Morretta, Andrea Spallarossa, Maria Chiara Monti, Camillo Rosano, Erika Iervasi, Marco Ponassi, Matteo Mori, Fiorella Meneghetti, Chiara Brullo   +9 more
wiley   +1 more source

First Diagnosed Case of Steroid-induced Kaposi's Sarcoma in Mongolia

Central Asian Journal of Medical Sciences, 2016
Objectives: Kaposi's sarcoma (KS) is a vascular neoplasm with four main types. We report the first diagnosed case of steroid-induced KS in a non-HIV patient in Mongolia.
Khandsuren Byamba, Ariunaa Munkhbayar, Oyuntsatsral Batsaikhan, Undram Sainzaya   +3 more
doaj   +1 more source

Human herpesvirus 8 infection in children and adults in a population-based study in rural Uganda.

Journal of Infectious Diseases, 2011
BACKGROUND Human herpesvirus 8 (HHV-8) infection is endemic in sub-Saharan Africa. We examined sociodemographic, behavioral, and biological factors associated with HHV-8 infection in children and adults to determine HHV-8 seroprevalence and potential ...
L. Butler, W. Were, S. Balinandi, R. Downing, S. Dollard, T. Neilands, Sundeep K. Gupta, G. Rutherford, J. Mermin   +8 more
semanticscholar   +1 more source